Synthesis of 1-naphthoyl chloride

[WillD]

Reaction scheme:

Synthesis:
1. In the reactor, equipped with a stirrer, a thermometer, reflux condenser and a drip funnel, add 600 g POCl3.
2. In the drip funnel poured 1000 g 1-naphthoic acid and 500 ml dimethylformamide.
3. The reaction mass is heated to 100 *С. Within 30 minutes, the mixture was added from a drip funnel.
4. Then the reflux condenser was changed to straight condenser and distill the forming propionyl chloride.
5. The resulting 1-naphthoic acid chloride is distilled at 35 mm pressure at a temperature of 190 *С. 1170 g 1-naphthoic acid chloranhydride was obtained (yield 93%).

 

[G.Patton]

 

[jarmy]

View attachment 6522

G.PattonIs there a better way to synthesize 1-naphthoyl chloride

 

[jarmy]

Reaction scheme:
View attachment 1698
Synthesis:
1. In the reactor, equipped with a stirrer, a thermometer, reflux condenser and a drip funnel, add 600 g POCl3.
2. In the drip funnel poured 1000 g 1-naphthoic acid and 500 ml dimethylformamide.
3. The reaction mass is heated to 100 *С. Within 30 minutes, the mixture was added from a drip funnel.
4. Then the reflux condenser was changed to straight condenser and distill the forming propionyl chloride.
5. The resulting 1-naphthoic acid chloride is distilled at 35 mm pressure at a temperature of 190 *С. 1170 g 1-naphthoic acid chloranhydride was obtained (yield 93%).

William DampierThank you for all

 

[G.Patton]

Is there a better way to synthesize 1-naphthoyl chloride

jarmyThese are best options =)

 

[jarmy]

Thank you my friend

 

[Khaled]

Can I use Benzoyl Chloride 99% instead of Naphthoyl Chloride?

 

[G.Patton]

Can I use Benzoyl Chloride 99% instead of Naphthoyl Chloride?

Khaledno

 

[D4ftmonk]

Is it right to be like this?

 

[thankyou888]

Is it right to be like this?
View attachment 8553

D4ftmonkIs this 1-naphthoyl chloride made with Naphthoic acid and pocl3.?

 

[G.Patton]

Is it right to be like this?
View attachment 8553

D4ftmonk1-naphthoyl chloride is melt at 16-19 *C.

 

[thankyou888]

@G.Patton
If we add HCl in Naphthoic acid than it will not produce Naphthoyl chloride.?

 

[G.Patton]

@G.Patton
If we add HCl in Naphthoic acid than it will not produce Naphthoyl chloride.?

thankyou888No.

 

[thankyou888]

No.

G.PattonRed coloured product and waste is solidified. The product is correct or it is something else.

 

[thankyou888]

No.

G.PattonBut the yield is very low. With 100g Naphthoic acid it only formed 18g of product.
Actually there were two things.
(1) added 30g extra DMF to dissolve Naphthoic acid properly.
(2) due to unexpected reason the reaction mass was left overnight.

 

[thankyou888]

But the yield is very low. With 100g Naphthoic acid it only formed 18g of product.
Actually there were two things.
(1) added 30g extra DMF to dissolve Naphthoic acid properly.
(2) due to unexpected reason the reaction mass was left overnight.

thankyou888@G.Patton
When carried out properly. Result looks like this. But still the yield is very less than expected ~45g. Can you explain the reason behind it.?

 

[G.Patton]

Red coloured product and waste is solidified. The product is correct or it is something else.
View attachment 8686 View attachment 8685

thankyou888Hello, I can't answer about product by the picture. You have to check melting point.

 

[G.Patton]

@G.Patton
When carried out properly. Result looks like this. But still the yield is very less than expected ~45g. Can you explain the reason behind it.?
View attachment 8710

thankyou888>>>(2) due to unexpected reason the reaction mass was left overnight.
evaporated, I guess

 

[Khaled]

Hello, how are you? Can I inquire about the alternative to naphthoyl chloride? How many substances can you write down?

 

[thankyou888]

Hello, how are you? Can I inquire about the alternative to naphthoyl chloride? How many substances can you write down?

KhaledYou can use many other reagents but than final product is not JWH-018. It will produce other series of cannabinoid.

 

[jarmy]

You can use many other reagents but than final product is not JWH-018. It will produce other series of cannabinoid.

thankyou888Thank you for all

Can you tell us what are the alternative reagents for naphthoyl chloride, because we find it difficult to manufacture and obtain it?

 

[thankyou888]

Thank you for all

Can you tell us what are the alternative reagents for naphthoyl chloride, because we find it difficult to manufacture and obtain it?

jarmyYou can easily get this reagent from china.

 

[thankyou888]

@G.Patton also tell me how to clear the solid waste formed inside reactor.?
Does alcoholic NaOH will clean the reactor.?

 

[G.Patton]

@G.Patton also tell me how to clear the solid waste formed inside reactor.?
Does alcoholic NaOH will clean the reactor.?

thankyou888Yes, It can cope with it.