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Mephedrone synthesis

α-PVP/MDPV synthesis from 2-Bromovalerophenone

Mephedrone hydrobromide synthesis

2-Bromo-4'-methylpropiophenone synthesis from 4'-methylpropiophenone

2-Bromovalerophenone synthesis from valerophenone

2-Iodo-4'-methylpropiophenone synthesis from 4'-methylpropiophenone

4-MMC (mephedrone) synthesis. Complete video tutorial.

Mephedrone synthesis

Reactions: Mr Good Cat, trenchwalker, d34dincid3 and 13 others

48% is not to much you get ...

Bhuro
Aug 4, 2022
5.00 star(s)

excellent work like all time.i'm really glad if you make video instruction on valerophenone.

Breaking Bad is an amazing forum standing out of the crowd thanks to this kind of post and instructive videos.

Hello could someone please test if Oxidizing of Ephedrine to Methcathinone (''Ephedrone'') with H2O2 works.Thank you very much

what is the difference between Mephedrone hydrobromide synthesis and this?

Hank Shrader said:
what is the difference between Mephedrone hydrobromide synthesis and this?

Does this description tell you something?

from 2-iodo-4'-methylpropiophenone with ethyl acetate

G.Patton said:
Does this description tell you something?

yes, but I wanted to understand if the quality of the product obtained is the same or if something changes

Hank Shrader said:
yes, but I wanted to understand if the quality of the product obtained is the same or if something changes

The 4mms molecule is the same, the quality as well.

Bhuro said:
excellent work like all time.i'm really glad if you make video instruction on valerophenone.

it's the same process, just buy the 2-bromo-valerophenone precursor and add pyrrolidin instead of methylamine and you have a-pvp. That's why i love sn2 reactions they are just so simple

is t possible to make on this way 3mmc? can anybody help!

Me too i want some help but i want synthesis pentedrone

studentt said:
is t possible to make on this way 3mmc? can anybody help!

Can I get a help . Lodketon I searched about it haven't find . In which formula can I find . Or other names for this products

G.Patton said:
Cząsteczka 4 mm jest taka sama, jakość również.

Hi bro i dont need heat this when im put M40% only im mix 20min and later put pure water ??

StarWars said:
Hi bro i dont need heat this when im put M40% only im mix 20min and later put pure water ??

You have to avoid overheating, and external heating isn't necessary.

E
EIS
Jan 20, 2023

Hello , I have a question, How much Hydrobromic should be added in this video, it is not written there. Thank you in advance

EIS said:
Hello , I have a question, How much Hydrobromic should be added in this video, it is not written there. Thank you in advance

Put and check pH with papier pH u check to pH 6

E
EIS
Jan 20, 2023

Hi , Is there a way to make crystals faster using this recipe?

E
EIS
Jan 20, 2023

StarWars said:
Put and check pH with papier pH u check to pH 6

Ok , thanks

EIS said:
Hi , Is there a way to make crystals faster using this recipe?

Yes in 24h u can get

E
EIS
Jan 22, 2023

Who can help with the choice of equipment , I need to make a volume of 18 kg per day, which reactor, flasks, vacuum to use ?

E
EIS
Jan 22, 2023

A solution of isopropyl alcohol and pure water (30:70) was prepared. 30 isopropyl alcohol and 70 water?

@Novator @G.Patton Can this be scaled? I like the reagents better than the look of the other mephedrone synths posted. I have a reactor with nice heater/chiller is the problem with scaling the heat generated? What is the target tempurature for this reaction? Thanks

chuckmcgill said:
Can this be scaled?

Hello, yes it can.

chuckmcgill said:
is the problem with scaling the heat generated? What is the target tempurature for this reaction?

There is no such problem, read the topic about this synthesis. (link under this video)

G.Patton said:
Hello, yes it can.

There is no such problem, read the topic about this synthesis. (link under this video)

The link under the video goes to a write up of a different synthesis in nmp. Is there a link to a write up about this synth? I dont see it, would it be ok to try this at 10x scale same ratio of everything? Thanks

chuckmcgill said:
The link under the video goes to a write up of a different synthesis in nmp. Is there a link to a write up about this synth? I dont see it, would it be ok to try this at 10x scale same ratio of everything? Thanks

You are right. Procedure conditions are same. You can scale all reagents x10 but I strongly recommend you to start from small scale synthesis.

Frit Buchner
Apr 2, 2023
5.00 star(s)

The captions sometimes disappear a little bit too quickly for me to read them. It seems like the videos / captions have sped up as time goes on. That being said, I always feel empowered and inspired after watching BB.expert videos, the production values are the absolute top of the genre.

R
Ra226
Apr 7, 2023

If I replace the raw material with phenyl(2-propyl)ketone (CAS 611-70-1), does it mean that I can directly synthesize methcathinone through this operation?

R
Ra226
Apr 7, 2023

Ra226 said:
If I replace the raw material with phenyl(2-propyl)ketone (CAS 611-70-1), does it mean that I can directly synthesize methcathinone through this operation?

Sorry, I misread the structure, I saw iodo as methyl.

G.Patton said:
You are right. Procedure conditions are same. You can scale all reagents x10 but I strongly recommend you to start from small scale synthesis.

Thanks appreciate the help! My problem is I have a 50l reactor and the mixer only works if there is at least 2 liters of liquid, maybe I could just add more Ethyl acetate?

chuckmcgill said:
Thanks appreciate the help! My problem is I have a 50l reactor and the mixer only works if there is at least 2 liters of liquid, maybe I could just add more Ethyl acetate?

It's worth to take smaller vessel, man.

G.Patton said:
It's worth to take smaller vessel, man.

ok I have 5 liter three neck flasks but I dont have an overhead mixer for them just magnetic mantle and it looks like it would be hard for that to stir this mixture properly getting a small reactor could take a few months but if you think it is isnt easy to do a bit bigger I can wait

chuckmcgill said:
just magnetic mantle

Do you mean magnetic mantle with stirrer? It doesn't take a reactor, you can carry it out in simple one neck flask and stir it manually or shake it manually in case you don't have a magnetic stirrer (it is the best option).

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G.Patton said:
Do you mean magnetic mantle with stirrer? It doesn't take a reactor, you can carry it out in simple one neck flask and stir it manually or shake it manually in case you don't have a magnetic stirrer (it is the best option).

yeah i have mantles with magnetic stirrer I just assumed because the powder product isnt very dissolved and there is a lot of it it might not stir with a stir bar. thanks again for your advice

Venom2021 said:
48% is not to much you get ...

Didn't mean it's not bad ass to learn

Yo my dude you got any the pyro mats?

Czy postępując zgodnie z instrukcja mogę zastąpić 2-Iodo ma 2-Bromo ?

I have a "little problem" with cristalization,if anyone more knowledgeable than me can write me a PM i whould apreciate it.
Best regards

Howbowtnobowl said:
I have a "little problem" with cristalization,if anyone more knowledgeable than me can write me a PM i whould apreciate it.
Best regards

With this chem or what chem do you refer to? Usually recreationalization and crystallization can come in a a and b process where acid base is used and solidifying into a liquid and the substance going into the Aquarius layer and or the acidic layer and separating out the gun can do and then using if it's based in aqueous layer for instance like today methamphetamine then you would use something like everclear very very little bit you would use acetone and at the very very least try to avoid but if needed a few drops of distilled water depending on the amount of your batch will vary independent on a lot of things you mainly want the more space it has to grow like he's in the crystals the bigger the crystals will be some substances don't properly crystallize a certain way unless they're salts and or it is very strong chemical to chemical it really does but for the simplicity of things it depends on what version of you have of the substance there's a lot of factors it may be if you could be a little bit more detailed I can try to help you out

Lol, I'm using voice to text so please forgive me I also went to and I missed out on the muriatic acid as the acidic layer is usually you know radic acid and we're just fine you can even up for the clean the Mirada acid but distilling it you know there's that it's just way some of the drunken nonsense you don't want but it is pretty good and you know then you got to watch your page levels and all that good stuff but just thought I'd throw it in there and mention that so if for some reason my wording is coming off as pretty stupid and dumb and ignorant it's probably because voice to text is being janky

@G.Patton @Novator how long roughly does amination usually take? What temperature does it normally heat to? I tried this at the scale listed, magnetic stirrer was no problem, the color change was not the same as the video, it slowly changed to green/yellow over two hours with a slight exothermic reaction from 13c to 22c, I added a little heat (50c) to try and cause it to react more, it slowly went to yellow/orange and then orange/brown over 20 hours. I was using homemade 40% aqueous methylamine solution that I made from methylamine hcl and naoh and I slowly adding 3x extra in case the solution was not a real 40%. Thanks

chuckmcgill said:
how long roughly does amination usually take? What temperature does it normally heat to? I tried this at the scale listed, magnetic stirrer was no problem, the color change was not the same as the video, it slowly changed to green/yellow over two hours with a slight exothermic reaction from 13c to 22c, I added a little heat (50c) to try and cause it to react more, it slowly went to yellow/orange and then orange/brown over 20 hours. I was using homemade 40% aqueous methylamine solution that I made from methylamine hcl and naoh and I slowly adding 3x extra in case the solution was not a real 40%. Thanks

It takes about 20 min as described in the topic. Are you sure that you've added correct amount of methylamine free base? Have you tried to finish your procedure in accordance with guide? Please, continue in the topic comment section (you can mark me to remind).

G.Patton said:
It takes about 20 min as described in the topic. Are you sure that you've added correct amount of methylamine free base? Have you tried to finish your procedure in accordance with guide? Please, continue in the topic comment section (you can mark me to remind).

I had to make the methylamine 40% from methylamine HCL. I used a post from this forum however the molar ratios seemed a little low in NaOH (40g MethylAmhcl 17g Naoh) but the poster said they had tried many recipes and found only slow addition of NaOH until Ph 12 produced proper results. When the reaction did not proceed quickly I slowly added more methylamine 40% until I had reached a 3x excess (750ml instead of 250ml).

I am following up on crystallization steps today hopefully they worked. Is there good information on the forum for making 40% Methylamine? The info seems to be asked for a lot because the HCl form is easier to get. Thank you!!

chuckmcgill said:
I used a post from this forum however the molar ratios seemed a little low in NaOH (40g MethylAmhcl 17g Naoh)

It seems that you take not enough NaOH. 40g Methylamine*HCl is 0.59 mole and 17 g NaOH is 0.425 moles. You have to take about the same or more moles of NaOH, man. What post do you mean? In addition, take into account that MeNH2 is very volatile substance and evaporates quite fast.

chuckmcgill said:
Is there good information on the forum for making 40% Methylamine?

How to properly generate Methylamine gas to Methanol

I have problem because I don't know how to properly generate Methylamine gas I putted 100 grams of Methylamine in 80g of water and mixed in one beaker Then I putted 200 grams of NaOH in erlenmeyer flask which was connected with silicone tubing to ice cold liebig condenser and then to Jar that...

bbgate.com

G.Patton said:
It seems that you take not enough NaOH. 40g Methylamine*HCl is 0.59 mole and 17 g NaOH is 0.425 moles. You have to take about the same or more moles of NaOH, man. What post do you mean? In addition, take into account that MeNH2 is very volatile substance and evaporates quite fast.

How to properly generate Methylamine gas to Methanol

I have problem because I don't know how to properly generate Methylamine gas I putted 100 grams of Methylamine in 80g of water and mixed in one beaker Then I putted 200 grams of NaOH in erlenmeyer flask which was connected with silicone tubing to ice cold liebig condenser and then to Jar that...

bbgate.com

This post. He seemed like he had done a bunch of specific work so even though the molar ratios were off I tried it. Your post relates to bubbling into methanol and the synth I am using calls for it in water. Thanks. The thread i followed was https://bbgate.com/threads/using-methylamine-hcl-successfully-in-4mmc-synthesis.5641/

Venom2021 said:
48% is not to much you get ...

chuckmcgill said:
@G.Patton @Novator how long roughly does amination usually take? What temperature does it normally heat to? I tried this at the scale listed, magnetic stirrer was no problem, the color change was not the same as the video, it slowly changed to green/yellow over two hours with a slight exothermic reaction from 13c to 22c, I added a little heat (50c) to try and cause it to react more, it slowly went to yellow/orange and then orange/brown over 20 hours. I was using homemade 40% aqueous methylamine solution that I made from methylamine hcl and naoh and I slowly adding 3x extra in case the solution was not a real 40%. Thanks

I have encountered the same problem as you. Using methylamine hydrochloride and sodium hydroxide also requires heating, and the color changes from green to yellow. Did you synthesize iodone by yourself? Did you finally synthesize 4-MMC successfully?

G.Patton said:
Does this description tell you something?

Dear Mr. Patton, I have a curiosity which you have advised me to satisfy. Can you explain which solvents to use and create conditions for the synthesis of Clephedron from 2-brom-3-chloropropiophenon? I understand that this synthesis is similar to the synthesis of Mephedrone, but the precursors of these methcathinones have different states of aggregation and I think that this fact can affect the choice of solvent to some extent. I will be very grateful if you explain this synthesis?

Epikureetsdrug said:
Dear Mr. Patton, I have a curiosity which you have advised me to satisfy. Can you explain which solvents to use and create conditions for the synthesis of Clephedron from 2-brom-3-chloropropiophenon? I understand that this synthesis is similar to the synthesis of Mephedrone, but the precursors of these methcathinones have different states of aggregation and I think that this fact can affect the choice of solvent to some extent. I will be very grateful if you explain this synthesis?

Hello, you need 2-bromo-4'-chloropropiophenone CAS 877-37-2 for synthesis of 4-Chloromethcathinone (Clephedrone). So far as solvent in this synthesis concerned, I can't answer you because Idk for sure. I would try same solvents as for 4-mmc at first. I haven't found exact information about this synthesis.

Ra226 said:
If I replace the raw material with phenyl(2-propyl)ketone (CAS 611-70-1), does it mean that I can directly synthesize methcathinone through this operation?

no buddy. this reaction is sn2, so you need a nucleophilic agent, and your ketone is not.

G.Patton said:
Hello, you need 2-bromo-4'-chloropropiophenone CAS 877-37-2 for synthesis of 4-Chloromethcathinone (Clephedrone). So far as solvent in this synthesis concerned, I can't answer you because Idk for sure. I would try same solvents as for 4-mmc at first. I haven't found exact information about this synthesis.

my respect

the fact is that I have 3-chloropropiophenone (cas: 34911-51-8) available, which differs from 4-chloropropiophenone only in that it is a liquid, but I want to get exactly 3-cmc. So thank you very much for your response to the previous post. And on this occasion, I have the last 2 questions: 1. What role does NMP play in such syntheses and is it possible to do without it at all? and 2. Did you choose the quantities of reagents (participants in the reaction) based on the coefficients in the equation of this reaction or from the consideration that a cheap component should be taken in excess?

Based on this video, this synthesis uses 0.55mol (125g) BK-4 and 2.9mol (250ml*0.9g/ml*0.4=90g) methylamine. What caused the need for an almost sixfold excess of methylamine? And can this negatively affect the yield of the final product? Or maybe I'm wrong in my calculations?

Epikureetsdrug said:
1. What role does NMP play in such syntheses and is it possible to do without it at all?

This play role of dipolar aprotic solvents. Have you read this post? https://bbgate.com/threads/mephedrone-synthesis-4-mmc-in-nmp-solvent-large-scale.231/

Epikureetsdrug said:
2. Did you choose the quantities of reagents (participants in the reaction) based on the coefficients in the equation of this reaction or from the consideration that a cheap component should be taken in excess?

It was written in accordance with the reaction equation and great synthesis experience.

Epikureetsdrug said:
What caused the need for an almost sixfold excess of methylamine?

Methylamine in this reaction works as N-nucleophile and base catalyst

Epikureetsdrug said:
And can this negatively affect the yield of the final product?

Are you talking about the excess of methylamine? You can get rid of this quite easy during water washing and/or evaporation after synthesis.

G.Patton said:
This play role of dipolar aprotic solvents. Have you read this post? https://bbgate.com/threads/mephedrone-synthesis-4-mmc-in-nmp-solvent-large-scale.231/

It was written in accordance with the reaction equation and great synthesis experience.

Methylamine in this reaction works as N-nucleophile and base catalyst

Are you talking about the excess of methylamine? You can get rid of this quite easy during water washing and/or evaporation after synthesis.

quite detailed and clear answer, thank you very much. Armed with this information, I am going to conquer this substance right now.

I will return with a shield, or on it.

how can i make 2iodo-4methylpropiophenone if i have 4methylpropiophenone and some iod?

What's govern on?

Last edited: Jun 22, 2023

M
maloo
Aug 7, 2023

I know it indicated in text that reactions are provided without a vacuum. I just wanted to confirm if this means that the reaction can be complete at normal atmospheric pressure? And that a sealed reaction vessel isnt required?

Is 35% HCl solution suitable for acidification?

Venom2021 said:
48% is not to much you get ...

Suggestions for higher %?

H
havencroft
Sep 22, 2023
4.00 star(s)

What is lodketone I can't find on the internet?

Marocamora
Oct 1, 2023
5.00 star(s)

Great job I want to know is mephedrone similar to cocaine? Does it have the same effects and does it also cause greenness in the tongue like cocaine? And can it be consumed in powder form without becoming crystal?

Marocamora said:
Great job I want to know is mephedrone similar to cocaine? Does it have the same effects and does it also cause greenness in the tongue like cocaine? And can it be consumed in powder form without becoming crystal?

Mephedrone is similar in action to cocaine and mdma. With nosal use, the duration of action is 40 minutes, causes strong euphoria with light stimulation. Very strongly stimulates sexual desire.

Brumer.com said:
We have 2-iodo-4-methylpropiophenone. now in stock

Brumer - reliable supplier of hard-to-find chemicals

Nitroethane, methylamine, benzaldehyde, methylpropiophenone, 2-bromo-4-methylpropiophenone, 2-iodo-4-methylpropiophenone are already available. Shipping worldwide! flexible payment terms, safe delivery. We take into account the wishes of customers and even offer discounts!

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Hello, please, I want to buy large quantities of materials from your site, but I sent you an email and none of you answered me.

Why not acidify with HCl gas?

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