2-bromo-4-chloropropiohenone synthesis. (HBr/H2O2 ?)

ZhengJi

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I found an instruction for synthesis 2-bromo-4-chloropropiohenone:

"A solution of 15.9 g (0.1 mol) of bromine in 20 ml of chloroform is added dropwise to a solution of 16.8 g (0.1 mol) of 4'-chloropropiophenone in 100 ml of chloroform, in the presence of a small amount of aluminium chloride, and the mixture is stirred overnight. After filtration and evaporation of the filtrate, the crystalline residue is washed with petroleum ether. When dry, it melts at 75° C."

But there is a question:
Is it possible to use HBr/H2O2 method like in 2-bromo-4methylpropiohenone case?
 

HIGGS BOSSON

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I found an instruction for synthesis 2-bromo-4-chloropropiohenone:

"A solution of 15.9 g (0.1 mol) of bromine in 20 ml of chloroform is added dropwise to a solution of 16.8 g (0.1 mol) of 4'-chloropropiophenone in 100 ml of chloroform, in the presence of a small amount of aluminium chloride, and the mixture is stirred overnight. After filtration and evaporation of the filtrate, the crystalline residue is washed with petroleum ether. When dry, it melts at 75° C."

But there is a question:
Is it possible to use HBr/H2O2 method like in 2-bromo-4methylpropiohenone case?
ZhengJi
But there is a question:
Is it possible to use HBr/H2O2 method like in 2-bromo-4methylpropiohenone case?

Yes, the reaction proceeds similarly with all types of propiophenones
 
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