3 pot cocaine HCL in high yield from Chinese precursor?

[Frit Buchner]

The synthesis

US20210069173A1 - Preparation of (-)-cocaine hydrochloride - Google Patents

Efficient methods are provided for large scale production of ethyl cocaine-free cocaine hydrochloride. Compositions and methods comprising administration of cocaine hydrochloride are provided.

patents.google.com

One of many examples of the product

This product is no longer available.

This product is no longer available.

m.alibaba.com

This is currently novel idea in my mind, but the precursors/ yield ratio appears to be far more efficacious than prior art. I haven't read this lately, but I recall thinking I could eliminate the continuous process by switching it for a batch process, and I remember researching and -40°c was the bottom range of dry ice
I just want to open a dialogue on the subject and discuss it with you

 

[Edwganz]

May be on to something yet can you explain more what you want to accomplish? Synthesize cocaine?

 

[Frit Buchner]

Not me obviously. Someone with the knowledge and equipment to do such a thing would say that it costs as much to synthesize as it does to just buy it on the street. For the average hobbiest, it would cost easily 20x as much to arrive at this point in the synthesis of a tropane alkaloid. My friends concern is mostly about receiving it in the mail

 

[Edwganz]

Not me obviously. Someone with the knowledge and equipment to do such a thing would say that it costs as much to synthesize as it does to just buy it on the street. For the average hobbiest, it would cost easily 20x as much to arrive at this point in the synthesis of a tropane alkaloid. My friends concern is mostly about receiving it in the mail

tropaneCool cool. I concur--it would cost a lot to synthesize and until 2019 wasn't even possible. Wish I could help your friend out with his or her concern. Just an idea as to where to start: what does the MSDS sheet say about the chemical? Also the shipper from Alibaba should have other clients and reviews. My experience has been that they know pretty well what the risks are since the purchase has some protection and could hurt them. If they say no problem then it's good.

That said wouldn't it be cool to synthesize cocaine in a yeast bug? Biosynthesis but it's the same end product. That's what I have people doing. Soon it will be a reality and commercially viable.

 

[Frit Buchner]

The MSDS says it's pretty nasty and requires an entire hazmat suit to work with. I don't see the Chinese being too concerned with US law. These are corporations, and charging an individual Chinese National with an American crime would be moot if they can't be extradited. These chemical plants are offering a lot of direct precursors but they don't have any reviews from Americans specifically. Recently I've seen some articles about some scientists having CRISPR modified an Australian tobacco plant to biosynthasize cocaine. If you employ that kind of knowledge and equipment, you could do like the Chinese and just infringe the patent

 

[Edwganz]

Nasty chemical? Hazmat suit? Dang what is your "friend" making? Don't answer he he. Sounds amazing. So just becaues it's nasty doesn't mean it would cause a problem. It's all on the seller to comply with packaging requirements. There needs to be a lot of trust toward them to comply, or what I imagine the Chinese would do is simply label it as something different and say "No worry no worry". The fact that there are no American reviews tells me they don't even have friends there to create a fake review. It sounds like a no go amigo sorry to say it. Any other providers with reviews? Perhaps not which is a sure confirmation.

Recently I've seen some articles about some scientists having CRISPR modified an Australian tobacco plant to biosynthasize cocaine.

Totally up on that mon ami. That's what we do, only there are no patents nor could there be on a naturally occuring gene like that. If there could be would you like to be the one who applies for the patent and try to enforce it? Funny joke. Ha ha.

 

[Frit Buchner]

I used to be a mushroom farmer years ago and I read about patents. You're misinformed. A copy paste for you;
e United States Patent and Trademark Office (USPTO) issues plant patents for new and distinct asexually-reproduced plants, and utility patents for eligible patent-related inventions including genes, traits, methods, and plant parts.Aug 25, 2021

https://www.uspto.gov › patent-policy

Plant and plant variety protection | USPTO​

 

[Edwganz]

PVPs. Totally up on it and remember when they created the distinction trying to adapt engineering patents to biology. Before that was the case of Taq polymerase which after being sold for 10 million was declared unpatentable because it was a natural gene. Though a GMO plant can be patented the protection covers the work done, in essence the unique genome qualities. No naturally occuring gene can be patented because well, it's natually occurring. That all said I take it you are a law abiding citezen of the US. I'm not. Jurisdiction MFers! Looks like soon I'll be growing me some cocabacco. If we can load it up with THC and peyote genes that would be perfect. Are you down? What would we call it? I vote for maricocabaccoyote.

That would be cool though to try to patent a cocaine producing organism. No problem there.