4'-Methylpropiophenone iodination to 2-iodo-4'-methylpropiophenone by iodine/cooper(II) oxide. Video manual.

[Venom2021]

Preparation 2-iodo-4-methylpropiophenone The so-called iodoketone Place in a beaker 4-methylpropiophenone 150ml (148.90g) N-iodosucinimide 270g P-Toulenesulfonic acid monohydrate 228g We cover the glasses with a glass lid not tightly. We put it in the microwave and set it to 700w. We illuminate 3 times for 1 minute with 30-second breaks between sessions. We are waiting for the romance to cool down to temperature. Pour 300 ml of internal water with ice into the water and mix thoroughly. An iodoketone will arise almost immediately We filter on the filter and 2 or 3 more times We wash the water Crystallization 1g of iodoketone add 0.5ml or 0.7ml dcm mixed in a canister and put into the freezer -20 overnight After a night, filter it and then dry it. Yield 210g to 215g of pure iodoketone will me ok ??

 

[Katty Korner]

Preparation 2-iodo-4-methylpropiophenone The so-called iodoketone Place in a beaker 4-methylpropiophenone 150ml (148.90g) N-iodosucinimide 270g P-Toulenesulfonic acid monohydrate 228g We cover the glasses with a glass lid not tightly. We put it in the microwave and set it to 700w. We illuminate 3 times for 1 minute with 30-second breaks between sessions. We are waiting for the romance to cool down to temperature. Pour 300 ml of internal water with ice into the water and mix thoroughly. An iodoketone will arise almost immediately We filter on the filter and 2 or 3 more times We wash the water Crystallization 1g of iodoketone add 0.5ml or 0.7ml dcm mixed in a canister and put into the freezer -20 overnight After a night, filter it and then dry it. Yield 210g to 215g of pure iodoketone will me ok ??

Venom2021Anyway to replace the p toluene sulfonic acid.

 

[4-MMC118]

Iodine use CAS7553-56-2 or CAS 12190-71-5?

 

[Precursor-supplier]

Iodine use CAS7553-56-2 or CAS 12190-71-5?

4-MMC118CAS 12190-71-5

 

[4-MMC118]

Can nano-copper oxide be used? Will post-processing be troublesome?

 

[Angel M. Richards]

Sure, propiophenone will produce methcathinone. The methods are the same, afaik; simply replace it and perform the arithmetic with moles, etc. But like the topic, I'm not a chemist either.