5-MeO-Tryptamine synthesis from melatonin

[Frit Buchner]

Someone should go that extra step and add a dimethylation before or in lieu of the acidification for

5-meo-dmt....(?)

 

[HerrHaber]

Someone should go that extra step and add a dimethylation before or in lieu of the acidification for

5-meo-dmt....(?)

tropaneIn the first step, hydrolysis of acetyl group (N-deprotection) can be done both with acid either base (which I would go for), but this is probably not what you meant by acidification and it yields the primary amine (R-NH2) mexamine that can be further dialkilated (dimethyl is just a popular choice amongst many) and by preparative common sense the easy method of isolation and purification of the N,N-dialkyl-5-MeO-triptamine is by forming the hydrochloride salt with HCl therefore obtaining a stable white (in case of mexamine hydrochloride) solid substance instead of the brownish solid you'd better store in the freezer freebase.

 

[Frit Buchner]

I meant 5-meo-dmt, and that was my natural thought because it is smokable in that form and it is a natural form, occuring in plants and the secretion of Colorado river toads.vit is also easily prepared via dimethylation if the monamine the terminal position of the ethane moiety. It has a lot of demonstrated beneficial effects not demonstrated in the dialkyl variety and 30 mg dosage for a breakthrough experience