Acylation of Morphine Question

[Katty Korner]

So I've read that one can produce 6 MAM from glacial acetic acid, and catalytic amounts of sulfuric acid.

Does this work?

Also, does this work for other acids? Like propionic acid?

 

[Ig0r]

Hi Katty,

to answer your first question, yes it does although acetyl chloride is preferred with a Pd catalyst.
Propionic acid however requires diffrent circumstances in order to react.

Best regards

 

[Midget_Impinger]

I was told you could just substitute acetic anhydride with GAA and get mostly 6 MAM. Do you have any resources that show you need a catalyst for it?

 

[Katty Korner]

I was told you could just substitute acetic anhydride with GAA and get mostly 6 MAM. Do you have any resources that show you need a catalyst for it?

Midget_ImpingerIt's been consistently reported as needing one, but im following up with someone and it looks like it isn't necessary. Trying to sort out what is and isnt.

 

[kpn]

I was wondering about this too, would it be possible to get some 6-mam with just glacial acetic acid?

 

[kpn]

I get large amounts of morphine sulfate pills and want to convert them!

 

[rifta]

Hello, i'have tested and it don't seem to work ,with gaa alone and with sulfuric acid catalyst too, you must have anhydride