Buprenorphine synthesis and hydromorphone

[Jasonmorales77]

Someone can help me with this synthesis

 

[cokemuffin]

Not sure about buprenorphine, but as far as i know you make hydromorphone by just refluxing morphine in an acidic solution with a Pt or Pd catalyst

 

[Smasherunlocksit]

whats pd or a pt catalyst what kind of acid?

 

[HerrHaber]

Pd and Pt are noble metal catalysts most commonly found deposited on activated charcoal or other insoluble solid in 5 & 10% by weight concentrations from commercial sources. They are filterable and reusable solids that in presence of hydrogen would lead to the reduction of the substrate.

 

[Smasherunlocksit]

so lets say i had activated charcoal and glacial acetic acid thatd be the proper catalyst through re-fluxing to yeild hydromorphone?

 

[HerrHaber]

so lets say i had activated charcoal and glacial acetic acid thatd be the proper catalyst through re-fluxing to yeild hydromorphone?

SmasherunlocksitPd/C is not the same as C

 

[Smasherunlocksit]

how could one go about taking hydrochloride oxycodone and basifying in least complex manner or could i possibly some how make an actual vape juice that would be super viable theoretically?

 

[HerrHaber]

how could one go about taking hydrochloride oxycodone and basifying in least complex manner or could i possibly some how make an actual vape juice that would be super viable theoretically?

SmasherunlocksitCan’t recommend you vape the stuff because of the overdose risk that is imminent.