Exctract 2C-B from pills

[cubesquare]

Hi there.

I have a lot of 2C-B pills bought over the past few months and have found I prefer to snort the stuff. Crushed pills are horrible.

Is there a way I can crush them and then extract just the 2C-B from the tablet and discard the filler from the tablet?

I have about 80 pills of 20mg each...

 

[cubesquare]

I have read that an isopropyl alcohol wash will do this job very well. Any comments on that?
I have toluene for a process to convert 5-MeO-DMT HCL to freebase - could I use the toluene instead of isopropyl alcohol?

 

[tajira]

you will loose a lot of stuff bro, one pill is like 10 to 15 mg 2cb

 

[UWe9o12jkied91d]

Dissolve in minimal amount of water, filter solid junk, treat with aq. sol. of NaOH to obtain 2-cb freebase that you then extract and bubble dry hcl gas or aqueous HCl followed by removal of water by heat.
Full disclosure, I haven't done this, but it's the way I would approach it, maybe one of our experts can chime in?

 

[cubesquare]

you will loose a lot of stuff bro, one pill is like 10 to 15 mg 2cb

tajiraI don't care - I would rather have a clean snort than a lengthy ingestion. I have a large number of these things, if they each have 20mg, then I would have about 1.7g - if I walk away with 1g pure, I am happy...

 

[G.Patton]

Dissolve in minimal amount of water, filter solid junk, treat with aq. sol. of NaOH to obtain 2-cb freebase that you then extract and bubble dry hcl gas or aqueous HCl followed by removal of water by heat.
Full disclosure, I haven't done this, but it's the way I would approach it, maybe one of our experts can chime in?

UWe9o12jkied91dIt is correct. As @tajira said, you'll loose a lot during these manipulations.

 

[cubesquare]

It is correct. As @tajira said, you'll loose a lot during these manipulations.

G.PattonWhat kind of loss? 50% 80%?

As I said, I have 80 pills in my backup stash that I am never going to get to, if they contain 20mg each as advertised, that would mean there is around 1.6g of 2C-B in them.
If I can get ~1g I would consider that a win.

Thinking about the equipment I need and whatnot, it may be simpler for me to just buy pure 2C-B and farm these out to friends as gifts. Sigh - I wish I had a lab.

 

[cubesquare]

Ok - let me ask this in another way. If I crush these pills and dissolve in water, filter out the non-soluble stuff - what does that typically drop out? Micro-crystalline cellulose? Talc? I don't know what binding is being used in these.
And if I stop there and just evaporate off the water after filtering the solid waste, that would be good for my purposes because I could either insufflate the remaining substance or I could administer it via nasal spray (does 2C-B breakdown like cocaine in water using a 0.9% saline solution?)

My objective is to be able to snort this molecule without all the extra junk gumming my airways, so anything water soluble is going to be easier to deal with anyway.

 

[G.Patton]

What kind of loss? 50% 80%?

cubesquareI don't know for sure

typically drop out? Micro-crystalline cellulose? Talc?

I think so

And if I stop there and just evaporate off the water after filtering the solid waste, that would be good for my purposes because I could either insufflate the remaining substance or I could administer it via nasal spray (does 2C-B breakdown like cocaine in water using a 0.9% saline solution?)

Yes, salt form 2c-b is soluble in water

 

[cubesquare]

Yes, salt form 2c-b is soluble in water

G.PattonDoes the 2C-B degrade/breakdown when in water (like cocaine does) i.e. could it be stored in water in a nasal spray for longer than I could do with cocaine (which appears to be only a matter of hours...)

 

[UWe9o12jkied91d]

Does the 2C-B degrade/breakdown when in water (like cocaine does) i.e. could it be stored in water in a nasal spray for longer than I could do with cocaine (which appears to be only a matter of hours...)

cubesquareHydrochloride is very stable, should be A-OK

 

[cubesquare]

Well I have started a simple process.
I have taken 10 20mg 2C-B's and fine crushed them and added 50ml distilled water.
Busy passing this through a tiny funnel and coffee filter (all I have at the moment) and the amount of gunk that has stayed behind is staggering.

I will re-soak the leavings a few times to get the 2C-B out as much as possible (maybe three times?
And then Just leave this to evaporate dry over a period of time.

Question - if I leave the clarified distillate in the conical flask, could I heat that to accelerate evaporation and then once it has cooled, throw something that evaporates fast like ether, isopropyl acohol or toluene in to dissolve the 2C-B that has fixed to the inside of the flask and then pour that into a flat dish for rapid evaporation or is that a silly notion?

 

[cubesquare]

Just as FYI - the dry weight of the crushed pills was 2.960g. I will measure the waste and the product once it all dries and my process is cimplete - will give us some very basic insight into possible loss values

 

[G.Patton]

maybe three times?

cubesquareit would be enough

ether, isopropyl acohol or toluene

they won't dissolve 2c-b salt, it is better to do in Petri dish or simple dish with wide surface. and yes, you can heat it a little bit

 

[cubesquare]

it is better to do in Petri dish or simple dish with wide surface. and yes, you can heat it a little bit

G.PattonThanks - I have it on a stainless steel tray drying behind my wood fired stove - should dry overnight - will scrape and measure the output tomorrow.

 

[cubesquare]

Ok, I sped the drying process up in the oven, fan oven, set below 100 deg C. (looked like about 80).

I am left with 168mg of a dirty yellow/white residue - slightly waxy in texture.

If this was pure 2C-B then that would mean my yield is 16.8mg per tablet (advertised at 20mg) which would be pretty decent yield of 84%.

I have no doubt that this is not pure 2C-B though so my yield is definitely lower but a fun exercise non-the-less.
As it is slightly waxy, my desire to insufflate this is not going to be all that good, so I will dissolve all 168mg into 5ml of 0.9% saline and place into a nasal spray. As it dissolves with no problem this should be an easy administration method.

My nasal pumps give me 30 actuation's per 5ml, so at 168mg, this would give me 5.6mg of this 2C-B residue. 2 pumps should be a very decent dosage.

Second image is after adding the 5ml 0.9% saline - thw water has gone a slightly off white milky colour and there is sediment floating in it. This is start contrast to the clear water that went into the evaporating stage.

So, either the heat was too intense and I cooked something in the oven, or the evap/drying process has mucked with some of the adulterants/binders that were soluble in water and they have now come out or something in this didn't like saline solution. Granted, the clear water was over 100ml and this saline is only 5ml, but even during drying the water didn't change colour, so something definitely up.

I may sacrifice another 10 pills to trying this again and changing a few things.

1. teflon tray for drying
2. dissolve the tablets after crushing and allow to settle before filtering, stopping before sediment gets to filter.
3. Each successive wash would be allowed to settle.
4. use smaller amounts of water (30ml per wash not 50ml)
5. Allow for a slower natural evaporation (until I can get my hands on something to speed that up...)

Anyway - that is today's exercise in filtration and evaporation

 

[G.Patton]

You can recrystallize them or carry out A/B extraction to get pure 2C-B.

 

[cubesquare]

You can recrystallize them or carry out A/B extraction to get pure 2C-B.

G.PattonI am curious about how much actually made it through the process. A poor guessing game as I don't know for a fact what went into it...

After a night of settling in the saline though, you can see how much sediment made it into this stage (or came out because of the saline). I am going to filter this again and stop at this stage, give it a try later.

Next batch will be better

 

[Cypherdelic]

Snorting it is not nice IMO, I prefer oral.

 

[cubesquare]

Snorting it is not nice IMO, I prefer oral.

CypherdelicSnorting is shorter lived with a higher bio-availability (I assume as this is true of many other molecules) so it suits my lifestyle more.
I cannot consume a substance and drop out of my life for long periods of time, most often only in the evening after putting the kids to bed - this leaves me a very small window of opportunity to play.
Having a sharp onset, quick peak and then a relaxed drop off by the time I get into bed two hours later, means I get a fun night, a good nights rest and I don't jeopardise my lifestyle.

If I could take 2C-B as intended, I would have it on the back of an MDMA peak. Or after a candy flip MDMA peak. These things take many hours so I have to plan to not be at home, get sitters etc etc - this isn't easy so I elect to work within the constrains of my lifestyle

Anyway - snorting is harsh with 2C-B and the onset can be quite rough. The nasal spray idea removes the harshness of the snort completely and, if you space out your inhales by 5/10 minutes, softens the onset.

Sorry, not a lecture, just providing some context