First time going to do Sandmyer GABA to GHB synth...any advice ?

[methyllordir]

Hi nice people of BB,

So i'm gonna make some ghb through sandmyer reaction of GABA and Soduim nitrite, What do you guys recommend so I can do it successfully ?

I have all the common solvents and acids and stuff + glasses and I'm going with this toturial on EW

 

[cancan]

How about it, did you succeed?

 

[CCL4 huffer]

keep the nitrous acid very cold and use a huge exess also for maximum yield set up a gas trap with bicarb and at the very end of the reaktion add the contents of the trap back in to not only neutralise but also squeese the last bits of GHB out.