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Henry reaction for 1-phenyl-2-nitropropene (100-1000g+ scale, MW syn) P2NP

William Dampier

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Reaction scheme:
X6L7fNFRA2



Heat variant:
1. 1000 ml benzaldehyde, 1000 ml nitroethane, 250 ml glacial acetic acid and 50 ml n-butylamine was added in 10 L flask.
2. Install a condenser on the flask.
3. Start stirring and heat reaction mixture to 60 *C.
4. Heating mixture 2-3 hours.
5. Empty mixture in the bucket.
6. Add 800 ml IPA in the bucket and stirred.
7. Put the bucket in the freezer for 12 hours.
8. After that time, P2NP was crystallized.
9. Filtered and dried.

Microwave variant:
1. 100 ml benzaldehyde, 100 ml nitroethane, 25 ml glacial acetic acid and 20 ml n-butylamine was added in 500 ml glass.
2. Put a rubber glove on a glass.
3. The glass was put in the microwave.
4. Turn on the power of 750 W and warm so much time so that the mixture does not boil.
5. We repeat the step 4 several times, let me cool the mixture. Minimum 6 irradiations.
6. After that, add 100 ml IPA, stirred and put in the freezer for 12 hours.
7. After that time, P2NP was crystallized.
8. Filtered and dried.
 
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tankikan

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Reaction scheme:
View attachment 1298


Heat variant:
1. 1000ml benzaldehyde, 1000ml nitroethane, 250ml glacial acetic acid and 50ml n-butylamine was added in 10l flask.
2. Install condenser on the flask.
3. Start stirring and heat reaction mixture to 60*C.
4. Heating mixture 2-3 hours.
5. Empty mixture in the bucket.
6. Add 800ml IPA in the bucket and stirred.
7. Put the bucket in the freezer at 12 hours.
8. After that time P2NP was crystallized.
9. Filtered and dried.

Microwave variant:
1. 100ml benzaldehyde, 100ml nitroethane, 25ml glacial acetic acid and 20ml n-butylamine was added in 500ml glass.
2. Put a rubber glove on a glass.
3. The glass was put in the microwave.
4. Turn on the power of 750W and warm so much time so that the mixture does not boil.
5. We repeat the step 4 several times, let me cool the mixture. Minimum 6 irradiation.
6. After that, add 100ml IPA, stirred and put in the freezer for 12 hours.
7. After that time P2NP was crystallized.
8. Filtered and dried.
May i know if Nitromethane is equal to nitroethane?

And is it possible to use this item (as attached screenshot) as n-butylamine? If yes, how would you suggest to proceed?
 

Attachments

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Last edited:

William Dampier

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May i know if Nitromethane is equal to nitroethane?
No, these are different reagents. With nitromethane, we will get nitrostyrene. Nitromethane with some substituted benzaldehydes is suitable for the synthesis of the sources of a large class of substances, various psychedelic.
And is it possible to use this item (as attached screenshot) as n-butylamine? If yes, how would you suggest to proceed?
No
 
Last edited by a moderator:

Montecristo

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What is the yield for the heat method?
 

cyb3r0

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My friend, we can never get nitroethane, is there an alternative to it in this case?
 

HIGGS BOSSON

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My friend, we can never get nitroethane, is there an alternative to it in this case?
Problems with nitroethane in Europe began back in 2007, then gradually all countries put restrictions on this valuable reagent. And now there are two ways: to look for suppliers in countries where there is weak legislation with a developed chemical industry, for example, Bangladesh, or to synthesize independently, the methodology for this we have proposed.
 

anotherNovice

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I can find benzaldehyde for perfumery labeled CAS 100-57-2. Is this the same as required?
 

mactipo01

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hello!!
whats is ipa?
and how much methanphetamine can i get with the process?
ty beforhand :)
 

HIGGS BOSSON

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hello!!
whats is ipa?
and how much methanphetamine can i get with the process?
ty beforhand :)
In this topic, a method for obtaining phenylnitropropene, a precursor for the synthesis of amphetamine, is published. If you need methamphetamine, then look at the relevant topics. IPA - isopropyl alcohol

 
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mactipo01

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oh ty!!.. very nice....is very hard to learn this...and no simple to do it.
you perhaps
sell it? or know where i can buy some stimolant pills?
 

William Dampier

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oh ty!!.. very nice....is very hard to learn this...and no simple to do it.
you perhaps
sell it? or know where i can buy some stimolant pills?
Regarding this topic, we can help with the synthesis of P2NP. Other discussions in other topics
 

mactipo01

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sorry, i'm new...what is simple method to synthesis meth? P2NP or from ephedrine tablets?
 

William Dampier

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P2NP/Al/Hg, good route to start but difficult for large scales
 
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a_king

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how to get n-butylamen please
 

ASheSChem

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hi guys;
if we use cyclohexylamine, do we need glacial acetic acid ?
 
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