4-MMC (mephedrone) synthesis. Complete video tutorial.

[WillD]

I've tried mephedrone synthesis from 4 methylpropiophenone according to video that is uploaded on site and done the process with nmp but in crystallization process hcl was added but crystals wasn't appeared after freezing crystals was appeared but the main problem that I'm facing currently is the aceton wash whenever i was those crystals with ice cold acetone the crystals are dissolved in acetone and after drying crystals again appeared but without acetone washing crystals have burning taste and foul smells of chemicals... Suggest me what to do next ?

papajiMost likely bad quality acetone. There are few details, you have already written in private messages, we will continue there.

 

[vig212]

Same problem iam also facing. In fact the final product is bringing tears to eyes and is burning on tongue

 

[TheVacuumGuy]

Same problem iam also facing. In fact the final product is bringing tears to eyes and is burning on tongue

vig212Well, it should

 

[diogenes]

2-Bromo-4-Methylpropiophenone, a substance in the form of crystals. Ask the seller for what reason it is liquid? Perhaps he suggests 4-methylprophyophenone

HIGGS BOSSONHi, can someone please share a reliable supplier of 2-bromo-4-Methylpropiophenone or 4-methylpropiophenone in Europe please? PM ime if no ads in the forum here is allowed. Any advice on which one is safer (less watched) to obtain would also be appreciated. I can`t wait to try the synthesis in the video, but need to get some starting material.

 

[Bazooka90]

2L [3 neck] flask , Condenser for reflux, 250ml Constant pressure cylinder separatory funnel, thermometer adapter. ( all in the same size joint or double check you are buying compatible joints ) + 1000ml bulb seperatory funnel + few wide beakers + buechner funnel with vacuum flask ( or buechner funnel with hose adapter and normal flask) .
Retort stands, heating plate/mantle with magnetic stirrer, vacuum pump, glass rods, ph strips, filter membranes.

MontecristoFor the moment i can't find the 250ml Constant pressure cylinder separatory funnel. Do i have another option? Can someone gave an ideea?

 

[G.Patton]

separatory funnel

Bazooka90

 

[Bazooka90]

G.PattonThanx mate, my mistake. I wanted to said

Constant Pressure Dropping Funnel. How can i improvize one?​

 

[G.Patton]

Thanx mate, my mistake. I wanted to said

Constant Pressure Dropping Funnel. How can i improvize one?​

Bazooka90You can attach Claisen adapter with usual drip funnel... Or drip drop by drop by eye dropper/Paster pipette from pharmacy.

 

[WundaBearz41]

"Methylamine 40% (aqueous solution) - 200 ml"

Can this be replaced with Methylamine HCI? I noticed this is a flakey powder has anyone tried this?

 

[WundaBearz41]

"Methylamine 40% (aqueous solution) - 200 ml"

Can this be replaced with Methylamine HCI? I noticed this is a flakey powder has anyone tried this?

WundaBearz41I found this, but no real solution at the end, I think the OP of this post got stuck as well:

http://bbzzzsvqcrqtki6umym6itiixfhni37ybtt7mkbjyxn2pgllzxf2qgyd.onion/threads/methylamine-hcl-usage.1135/#post-3791

 

[G.Patton]

I found this, but no real solution at the end, I think the OP of this post got stuck as well:

http://bbzzzsvqcrqtki6umym6itiixfhni37ybtt7mkbjyxn2pgllzxf2qgyd.onion/threads/methylamine-hcl-usage.1135/#post-3791

WundaBearz41Look at here here .

 

[Bazooka90]

Strarting with 100g 2br4m I have followed the steps like in the video but instead of benzene i have used toluen and instead of nmp i have used dmf.
My yield was only 10 grams of powder, i need to mention that instead of 55 hydrochloric acid i used a few drops becous i not sure if i know how to measure the PH. Any suggestion where i do wrong?

 

[G.Patton]

Any suggestion where i do wrong?

Bazooka90Hello. You already answered.

i need to mention that instead of 55 hydrochloric acid i used a few drops

Most of your product is in free base form. I'll make a topic about pH, will link you as soon as post it.

 

[Sitr1x]

Hey there, first time poster long time reader of the forums here and many other chemistry groups.

Firstly, much respect to the Experts here for helping out a community of aspiring chemists, you have given me faith and much more hope on my journey of learning, and once I have gained more knowledge with organic chemistry I hope to be able to give back in some way in the near future..

Anyway to the point of my post. I've recently been learning alot on the clear-net from Rhodium and erowid archives etc to expand my scope and understanding of common techniques used in chemistry in general and I do strongly believe I am slowly getting a good grasp on all the basics so to speak. However I guess you could say I've hit a brick wall and need some advice.

Initially my hope was to learn to produce Phenyl-2-propanone (P2P), then proceed to make Crystal Meth which I have used in the past.
However, without the proper equipment at the moment (Will soon be buying a distillation kit, proper glassware kit, Magnetic stirrer and Vaccum etc..) I honestly lost faith and became too discouraged in making any decent attempt.
I found a good source for obtaining Nitro-ethane for one of the synth's I was considering seriously through eBay, as a liquid form of 'Nail Brush Saver' along with other regeants but I still was hesitant in my ability without the equipment at hand currently.

So in the Meantime after this initial downfall I've been trying to keep positive and just soaking in as much as I can about Organic Chemistry..

Anyway, I then happened to stumble across this site reading about it on other forums and found this amazing place where the content in much more fresh and the community seems alot more educated than others I've seen and then I found this specific thread in particular which caught my attention. I really love the way the video was put together and have now shifted my focus to producing 4-MMC for the end product of my first legit experiment.

I'll soon have all of the equipment necessary to give it a real go and was hoping if I could request a couple of things without asking too much at the same time.

I've found access to all the ingredients except for a couple of obvious ones as I believe they are quite tightly controlled generally as far as I'm aware.

The regeants I'm talking about are 4-methylpropiophenone and Methylamine Hydrochloride (40% Aqueous Solution).

I have read both of links I've attached below regarding production from scratch. However, I was wondering firstly with the Methylamine, is there a way to scale the whole recipe down while still using that exact same video method in the thread there. It would really help me by making my first attempts more affordable as a whole. Or is the a smaller scale method on here you could point me to that would also be great =)

Methylamine Hydrochloride-synthesis-large-scale

In regards to scale size the proposed method below I found for 4-methylpropiophenone is workable for me, however at this stage I was hoping an expert here could possibly (pretty please) do an in depth video, or point me in the right direction for a good method that is a little more 'amateur chemist' friendly lol?

Synthesis-of-4-methylpropiophenone-from-toluene-by-friedel-crafts-reaction-1kg-scale

Thanks for your time guys and girls, and I hope to keep you all updated on my journeys and trail runs in the near future. I'm very dedicated to learning as much as possible and any help is much appreciated. Please PM me if you feel more comfortable in discussing things that way.

Cheers,
Sitr1x.

 

[Sitr1x]

Most likely bad quality acetone. There are few details, you have already written in private messages, we will continue there.

William DampierThis was my initial thought as well as I've read similar problems with other synth's on threads in the past.

So I assume that one would need to synthesize the acetone themselves or can you still get away with using acetone from the store? Or is there a specific purity I should look for when it comes to this kind of Chemistry I should follow? Thanks

 

[Sitr1x]

As I was too busy reading, I didn't realize that the Methylamine synthesis video which I downloaded in the background that I mentioned in my earlier post is actually done on a decent starting scale lol

So please disregard that part. Am just going to have to wait until I get my proper glassware and distillation kit it looks like.

 

[ShiftingWaterfall]

does somebody here know the difference in effects of racemic 4mmc compare to Enantiomer 4mmc? i want to know if its worth to make it

 

[WundaBearz41]

In regards to scale size the proposed method below I found for 4-methylpropiophenone is workable for me, however at this stage I was hoping an expert here could possibly (pretty please) do an in depth video, or point me in the right direction for a good method that is a little more 'amateur chemist' friendly lol?

Synthesis-of-4-methylpropiophenone-from-toluene-by-friedel-crafts-reaction-1kg-scale

Thanks for your time guys and girls, and I hope to keep you all updated on my journeys and trail runs in the near future. I'm very dedicated to learning as much as possible and any help is much appreciated. Please PM me if you feel more comfortable in discussing things that way.

Cheers,
Sitr1x.

Sitr1xYes! Good request I'd love that too.

 

[KWasd]

Hi. If I dissolve 2-bromo-4-methylpropiophenone in NMP, heat the whole thing to 40 degrees C, and only then add methylamine 40% in water, do I have to add it in batches so as not to exceed the mentioned 60 degrees C, or can I add it all at once? Only after adding methylamine do I add cold water and benzene.

 

[WillD]

Hi. If I dissolve 2-bromo-4-methylpropiophenone in NMP, heat the whole thing to 40 degrees C, and only then add methylamine 40% in water, do I have to add it in batches so as not to exceed the mentioned 60 degrees C, or can I add it all at once? Only after adding methylamine do I add cold water and benzene.

KWasdYou can add all methylamine at once, and do not worry much about the high temperature.

 

[KWasd]

You can add all methylamine at once, and do not worry much about the high temperature.

William DampierThank you for your reply. I just noticed that when adding methylamine 40% in water to a solution of 2-bromo-4-methylpropiophenone in NMP (heated to 40 degrees C), the temperature jumped sharply to 60 several degrees. Hence my concern.

In the end, the product came out blue anyway, impossible to rinse with acetone, but this was due to the fact that the acetone was not ice-cold (I didn't have dry ice to cool it) and was room temperature. Hence, probably a mass of impurities and degradation / conversion to dimmer.

Nevertheless, thanks again