Methamphetamine Synthesis from Ephedrine by Using I2 and H3PO2

[kackbratze]

hello, i have a question: instead of Iodine could Potassium Iodine beeing used? Becaus Potassium Idodine is purchased much more easily.

 

[Throw-off]

You can use pottasium iodine to make iodine. It can be done in a lazy Sunday afternoon.

 

[waltjr5858]

It can be done in about 20 minutes

 

[xp7291]

I have a question. In Figure 12, the pH value has reached 12, which means free alkali can be produced. Why do we need to add sodium thiosulfate? In Figure 13?

 

[SoldadoDeDrogas]

To eliminate excess iodine and other potential byproducts that might carry over into the salt.

 

[darthseres]

A simple technical/theoretical question... The reaction is an oxidation/reduction... Considering that the main elements are Iodine, Phosphorus and Ephedrine... what exactly is the precise role of each element? Which one is oxidized? Which one is reduced? And the third?... I'm a new student, forgive my ignorance

 

[SoldadoDeDrogas]

I have answered you in another thread. Please don't repeat the same question in multiple threads.

 

[chemypharma]

Hi everyone. I'm not a newbie at chemist, although be a newbie here in the Forum, but not an Expert also. So I ask any of the Experts here to make a write up about the reduction of methcathinone to meth, getting rid of the carbonyl group by reducing it to methylene group. I have searched across the net and across BB Expert and never saw any article, thread or comment on this. The closer I've got is the reduction of ephedrine to meth, like in this topic. I'm working nowadays on 4MMC and methcathinone synthesis starting from 4-methyl propiophenone and propiophenone by bromination with HBR and H2O2 and further methylamination with CH3NH2 40% aquous in ethyl acetate, following recipes I've found here in BB Expert and my work were plenty sucesssfull until now. I think this route is easier for me since I have a good raw material supply. As a result I have on stock almost a kilo of pure 4MMC hydrochloride and bearing half a kilo of methcathinone hydrochloride. I think it's not interesting for me reducing methcathinone hydrochloride to racemic ephedrine hydrochloride with NABH4 in ethanol like here: https://bbforum.org/en/threads/synthesis-of-ephedrine-hydrochloride-and-chemical-analysis.9537/. In theory, hydriodic acid generated in situ by H3PO2 and I2 reaction described here in this thread are able to get rid of the methcathinone carbonyl group resulting in Meth. Since HI can reduce OH group at ephedrine molecule to H, the fact the carbonyl group present at methcathinone molecule is prone to lose itself with spontaneous replacing by an OH group, due to the instability of methcathinone free base, generating pseudo ephedrine, (https://en.wikipedia.org/wiki/Methcathinone), and the well know hability of Hydrazine to get rid of the ketone group, replacing it by H by heating with a strong base like KOH in ethylene glycol, two theoretical ways to reduce methcathinone to meth is on the table. I want to discuss with the Experts here about the feasibility of methcathinone reduction with HI generated in situ by H3PO2 and I2 reaction and with hydrazine hydrate heating with strong base in ethylene glycol.

I - Would be the same recipe reducing ephedrine to meth discussed here? What about the proportionality between HI and the substrate replacing C-OH by C=O reduction? would be the same molar equivalence or more HI is necessary to do the job? what about the reflux temperature of the solution? and what about the time of reflux?

II - The hydrazine reduction of methcathinone to meth (Wolff–Kishner reduction) will afect the methylamino group? is it necessary to BOC protect this amino group? I've already read articles that claims yes but exist literature about it saying isn't necessary at all. Is it possible hydrazine to react with this methylamino group creating undesirable byproducts if no BOC protection is apllyed?

Surprisiling almost no data abouth methcathinone reduction to meth exists anywhere, what is a shame that force us only to especulate theoretically. Could any Expert here on this Forum contribute to elucidate this chalenge?!

 

[hestor_moffet]

dope. thx for sharing this

 

[A person who has never be]

Request for help: I have obtained ephedrine oxalate. Can I follow your steps exactly to produce methamphetamine? Or will I need to convert it to ephedrine hydrochloride?

 

[darthseres]

Think that you need to make the Hcl form... Anyway how you obtained that? Quantity? Could you give an honest contact seller for 10-20 gr?

 

[A person who has never be]

I extracted it myself from ephedra. I wonder which country you are in?

 

[darthseres]

Italy... I post you what I found to convert in Hcl...

 

[darthseres]

1. The solubility of ephedrine oxalate in water was small. The mother liquor contains pseudoephedrine oxalate.
2. add 8~10 times of water and 1. 5% activated carbon, boiling, filtration, filtrate under stirring add CALCIUM CHLORIDE solution to no longer produce precipitation or turbidity, can be obtained ephedrine hydrochloride solution... From : https://www.chembk.com/en/chem/Ephedrine hcl

 

[A person who has never be]

I'm sorry, I don't have a way to ship to Italy for you.

 

[darthseres]

Ok... But could you give me some info? Because i bought 20 seeds of ephedra sinica and have big space to plant them... How many seeds you planted? How many time to grow the plants? What procedure you have actuated to extract? And how much ephedrine/pseudoephedrine you collect? Thank you in advance...

 

[A person who has never be]

I don't cultivate it; I directly purchase ephedra extract. First, I soak it in ethanol for 12 hours, then alkalize it, and then extract it with oxalic acid. Currently, 100 grams can yield about 1.5 grams.

 

[GhostChemist]

We did not carry out reduction of ephedrine oxalate

 

[A person who has never be]

Can oxalic ephedrine be directly used to produce methamphetamine?

 

[darthseres]

... But you intend the ephedra extract that is contained for example in fat-burn ECAstack Pills?