My 3-CMC synthesis

[draconic123]

I think I figured out why my acidification doesn't work lol, i've been adding acid through metal funnel, so acid musu have reacted with metal before going in to 3cmc freebase, therefore reaction was off, is that possible?

 

[iheartamines]

I think I figured out why my acidification doesn't work lol, i've been adding acid through metal funnel, so acid musu have reacted with metal before going in to 3cmc freebase, therefore reaction was off, is that possible?

draconic123A few other things that may have cause it to fail.

1. You have too much unreacted precursor 2b3c, which is what is turning your rm dark black/purple
2. If you are working on the organic layer, you haven't added enough ice cold Acetone. Add 2.5 times the volume of your reaction mixture.

 

[xoxoxoxo]

A few other things that may have cause it to fail.

1. You have too much unreacted precursor 2b3c, which is what is turning your rm dark black/purple
2. If you are working on the organic layer, you haven't added enough ice cold Acetone. Add 2.5 times the volume of your reaction mixture.

iheartamineshe dont need acetone.