The Simplest recipes

[Frit Buchner]

The references were just researchers saying other researchers suggest that it might be active. There is no imperical data or personal experience reporting. No brain scan mri, or chemical or activity analysis.
Metabolic pathways and products hidden behind a pay wall means I can read the outline or summary, but Wiley online or research gate ect. Want me to pay $30 or something to see the entire document. I believe one paper eluded to 13 first pass metabolic processes, so yeah I'm aware there is more than 1.
MAO-a renders nn dmt inactive. MAO-b renders Phenylethylamine inactive. These are metabolic processes. To suggest that first pass metabolism is irrelevant is....insane. sure, you could shoot it up or smoke it to bypass some processes but I wouldn't say that makes it "irrelevant "

 

[41Dxflatline]

The references were just researchers saying other researchers suggest that it might be active. There is no imperical data or personal experience reporting. No brain scan mri, or chemical or activity analysis.
Metabolic pathways and products hidden behind a pay wall means I can read the outline or summary, but Wiley online or research gate ect. Want me to pay $30 or something to see the entire document. I believe one paper eluded to 13 first pass metabolic processes, so yeah I'm aware there is more than 1.
MAO-a renders nn dmt inactive. MAO-b renders Phenylethylamine inactive. These are metabolic processes. To suggest that first pass metabolism is irrelevant is....insane. sure, you could shoot it up or smoke it to bypass some processes but I wouldn't say that makes it "irrelevant "

Frit BuchnerIt absolutely is irrelevant to whether it's active or not when it can be bypassed. Are you high or something? By your own weird criteria of whats active or not you're saying DMT is inactive and that's an absolutely insane thing to say.

 

[41Dxflatline]

Are you high or something? Shit yes, stayed up all night learning about chirality and resolution of enantiomers and stereoisomers. At least you did post something that looks legitimate. IC50 of 100nm, for ht-5a? Are you sure you even want to call that active? It certainly doesn't compare to psilocin. Having to take 10x as much doesn't seem like an advantage, but then again tryptamines are my least favorite drug, so maybe it is . Dmt isn't orally active. Need those qualifying adverbs.

Frit BuchnerIt's definitely of a different character to eating mushrooms if you snort 4-aco as opposed to eating it to most who have tried it. Of course, you don't have to take 10x as much since you still get the psilocin metabolite as well along with any others. DMT isn't orally active because of first pass, which is why I was telling you first pass is irrelevant to whether something is active or not. Anyway, even if all things were equal between psilocin and 4-aco-dmt in regards to effect 4-aco-dmt would still be superior because it's far more stable.

There's a few anecdotes of how snorting 4-aco-dmt is different in this reddit thread:

https://www.reddit.com/r/4acodmt/comments/ma6lyc

 

[the right stuff]

I'll give you even odds that if you put spores of a psilocybe species on cow droppings loaded with 5-MeO-DMT you would come out with mushrooms containing 4,5-HO-MeO-DMT. This way you avoid a 10 step synthesis by growing a psychoactive mushroom that contains no illegal drug.”
-shulgin

 

[Frit Buchner]

I'll give you even odds that if you put spores of a psilocybe species on cow droppings loaded with 5-MeO-DMT you would come out with mushrooms containing 4,5-HO-MeO-DMT. This way you avoid a 10 step synthesis by growing a psychoactive mushroom that contains no illegal drug.”
-shulgin

the right stuffI'll have To write this out but I'm going to say no, you wouldn't get that as a product

 

[the right stuff]

I'll have To write this out but I'm going to say no, you wouldn't get that as a product

Frit BuchnerI love it when people prove shulgin wrong. Anything come of it?

 

[T0lek511]

Jenkem Is very easy to make it but for your health and your nose its not good.

 

[erstwhile]

Sourcing San Pedro is quite easy. Dried san pedro "skins" I'm told is a bit harder but doable. Extract that using "Cieolo" tek, get a Peyote vector graphic, get that made into a stamp and press Mescaline pills.

Making GHB is fairly simple as well. Especially if you can source GBL Gel or BDO remover.