Alcohol & DOx
Alcohol, also known as ethanol, is a depressant that affects the central nervous system and is one of the most commonly consumed recreational substances worldwide.
Alcohol acts on the GABA (gamma-aminobutyric acid) neurotransmitter system, enhancing its inhibitory effects. This leads to sedation, muscle relaxation, and decreased anxiety. It inhibits the activity of the excitatory neurotransmitter glutamate on NMDA receptors, leading to memory impairment and decreased alertness. Increases dopamine levels in the brain's reward pathways, leading to feelings of pleasure.
The DOx family refers to a group of amphetamine derivatives that act as potent, long-lasting psychedelic stimulants. Common members include DOB (2,5-dimethoxy-4-bromoamphetamine), DOC (2,5-dimethoxy-4-chloroamphetamine), and DOI (2,5-dimethoxy-4-iodoamphetamine).
The DOxs act primarily as agonists at the serotonin 5-HT2A receptor, leading to the psychedelic effects typical of this class. They also influence the release, reuptake, and/or receptor activity of neurotransmitters like dopamine and norepinephrine, which can lead to stimulant effects.
The combination of Alcohol and Doxs can lead to heightened intoxication and enhanced psychedelic experiences, which can be unpredictable.
Side Effects and Dangers:
- Neurological: Increased risk of seizures due to the excitatory nature of DOx compounds and the lowering of the seizure threshold by alcohol.
- Cardiovascular: Potential for tachycardia, hypertension, or other cardiovascular issues due to the stimulatory effects of DOx and vasodilatory effects of alcohol.
- Cognitive: Impaired judgment, increased risk-taking behavior, and potential for severe disorientation or psychosis.
- Gastrointestinal: Nausea, vomiting, and potential for dehydration.
- Hepatic: Increased liver strain due to concurrent metabolism of both substances.
- Overdosing: The stimulating effects of DOx may mask some of the depressant effects of alcohol, leading users to consume more alcohol than intended. This increases the risk of alcohol poisoning.
Some users report that alcohol can smooth out the come-up of DOx compounds, potentially reducing anxiety or feelings of restlessness.
Avoid co-consumption of alcohol and DOx to prevent unpredictable effects. If choosing to combine, start with a much lower dose of each substance than usual. Stay hydrated and in a safe environment. The safest sequence would be to take a small amount of alcohol before or after taking DOx. So that alcohol acts as a mild sedative against anxiety and overexcitation, respectively. However, be aware of possible side effects and risks.
Considering the above, we recommend treating this combination with great caution.
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