Pregabalin How can I synthesize

[lamer]

Pregabalin How can I synthesize
I couldn't find any resources, can you help me?​

 

[The-Hive]

Drugs market @rosechem sells it on the kg

 

[lamer]

I'm looking for synthesis

 

[The-Hive]

It’s cheaper to buy then to actually make

 

[lamer]

I found such a source, but I'm not sure if it's accurate and I don't have the necessary measurements.

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2. Pregabalin, also known as β-isobutyl-γ-Aminobutyric acid or Lyrica, is a medication used to treat epilepsy, neuropathic pain, anxiety disorders, and fibromyalgia.
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5. The synthesis of pregabalin involves several steps starting from 4-methyl-2-pentanone. Here's a brief overview of the synthesis process:
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8. Conversion of 4-methyl-2-pentanone to 4-methylvalerophenone: In this step, 4-methyl-2-pentanone is treated with ethylmagnesium bromide to yield 4-methylvalerophenone.
9. Formation of enamine: The 4-methylvalerophenone is reacted with cyclohexanone in the presence of base to form an enamine intermediate.
10. Alkylation: The enamine intermediate is alkylated with bromoacetic acid in the presence of base to form the key intermediate, 3-(2-bromoacetyl)-4-methylvalerophenone.
11. Cyclization: The key intermediate is cyclized with ammonia to form 3-(aminomethyl)-5-methyl-hexanoic acid, which is then converted to pregabalin by subsequent steps involving protection and deprotection of amino groups.
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13. The complete synthesis reaction can be represented as follows:
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16. Step 1: 4-methyl-2-pentanone + Ethylmagnesium bromide → 4-methylvalerophenone
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19. Step 2: 4-methylvalerophenone + Cyclohexanone + Base → Enamine intermediate
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22. Step 3: Enamine intermediate + Bromoacetic acid + Base → Key intermediate (3-(2-bromoacetyl)-4-methylvalerophenone)
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25. Step 4: Key intermediate + Ammonia + Protection/deprotection steps → Pregabalin

 

[bigrob]

some them material are quite expensive u can pick up a kg here for very cheap i would look into other avenues instead of synthesising this