I found such a source, but I'm not sure if it's accurate and I don't have the necessary measurements.
Pregabalin, also known as β-isobutyl-γ-Aminobutyric acid or Lyrica, is a medication used to treat epilepsy, neuropathic pain, anxiety disorders, and fibromyalgia.
The synthesis of pregabalin involves several steps starting from 4-methyl-2-pentanone. Here's a brief overview of the synthesis process:
Conversion of 4-methyl-2-pentanone to 4-methylvalerophenone: In this step, 4-methyl-2-pentanone is treated with ethylmagnesium bromide to yield 4-methylvalerophenone.
Formation of enamine: The 4-methylvalerophenone is reacted with cyclohexanone in the presence of base to form an enamine intermediate.
Alkylation: The enamine intermediate is alkylated with bromoacetic acid in the presence of base to form the key intermediate, 3-(2-bromoacetyl)-4-methylvalerophenone.
Cyclization: The key intermediate is cyclized with ammonia to form 3-(aminomethyl)-5-methyl-hexanoic acid, which is then converted to pregabalin by subsequent steps involving protection and deprotection of amino groups.
The complete synthesis reaction can be represented as follows: