leuckart amination

  1. William Dampier

    Leuckart amination of 1-phenyl-2-propanone to amphetamine and methamphetamine (smale scale)

    Amphetamine 1. A solution of 1-phenyl-2-propanone (0,827 g, 6.2 mmol) and formamide (3,5 ml) was heated at 160-170 *C for 16 h. 2. The mixture was cooled to room temperature, and 30% hydrogen peroxide (5 ml) was added. 3. After stirring for 15 min, the reaction mixture was extracted with...
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