mdma synthesis precursor

Rxn: Safrole -(Wacker Oxidation (PdCl2+Benzoquinone))-> MDP2P This step has been called the Wacker Oxidation. It uses PdCl2 as a catalyst to put and oxygen across a double bond. This step has been worked over many times so do not change the amounts for the fabled 'scale-up'. If you do this...

Stage 1. Synthesis of Piperonal. Extraction of piperine from black pepper has been demonstrated previously. Starting reagents and materials 5 g recrystallized piperine 100 + 50 ml THF 10 g Potassium permanganate + 200-300 ml water 800-1000 ml DCM 50-100 g anhydrous sodium sulfate 25 ml EtOH...