mescaline synthesis

Here I'll document my Mescaline synthesis from 3,4,5-trimethoxybenzaldehyde then after I optimize the reaction I'll write the documents. My goal is to achieve good yield using minimum catalyst and nitromethane. 3,4,5-trimethoxybenzaldehyde in a bag Experiment 1: 10g of...

I have tried to synthesize mescaline from 3,4,5-trimethoxybenzaldehyde via two different routes. Everything seemed to work well until the last step, yet no desired product was obtained. Does anyone have an idea of what might have gone wrong? My route was in principle the following: 1)...

TMA Synthesis by 1-(2,4,5-Trimethoxyphenyl)-2-nitropropene (3,4,5-TMPNP) LAH Reduction This synthesis of mescaline and TMA can be considered as a typical example of recovery using LAH. The differences in the production of mescaline and TMA are only one: for mescaline, it is necessary to take...

Reagents: 3,4,5-Trimethoxybenzaldehyde (cas 86-81-7) 1000 g; Acetic acid 5 L; Nitromethane (cas 75-52-5) 2 L; Cyclohexylamine (cas 108-91-8) 100 ml; Distilled water ~17 L; Isopropyl alcohol (IPA) ~23 L; Sodium borohydride (NaBH4) 1200 g; Copper chloride (CuCl2) 72 g; Sodium hydroxide (NaOH) 25%...