4-CMC synthesis

[Crystal__Chemist]

Hi
Please someone can help with synthesis 4-cmc. Im gonna use per one mole of bromoketone 4 moles of methylamine (40% solution in water). As a solvent im gona use dcm or toluene. What is the best time and what solvent is better and what temperature should be perfect. I don't whant use benzene becouse it is verry toxic.

 

[G.Patton]

Hi, procedure is the same as for 4-MMC.

 

[Crystal__Chemist]

So if I cook it for 2 h in 40°C i will get my product in good numbers ?

 

[mocnykutas]

So if I cook it for 2 h in 40°C i will get my product in good numbers ?

Crystal__ChemistU Dont heat it and dcm toulen benzen ethyl acetate no work

 

[Jesse_Pinkman_]

U Dont heat it and dcm toulen benzen ethyl acetate no work

mocnykutasEthylacetate works

 

[Bazooka90]

Ethylacetate works

Jesse_Pinkman_what temperature need for ethyl acetate?

 

[Crystal__Chemist]

Can I use dmso and toluene or dcm for this reaction ?

 

[mygodson]

That patton said is correct.

 

[Crystal__Chemist]

But what solvent is better while synthesis run with dmso : dcm or tolene?

 

[UWe9o12jkied91d]

But what solvent is better while synthesis run with dmso : dcm or tolene?

Crystal__ChemistOne non polar and one bipolar aprotic. for ex:

Toluene + NMP
DCM + DMSO

The point is to homogenize the mass until monophasic, this makes it go much faster.
You can alternatively react in just DCM overnight (8h)

OOPS SORRY FOR NECRO

 

[HerrHaber]

One non polar and one bipolar aprotic. for ex:

Toluene + NMP
DCM + DMSO

The point is to homogenize the mass until monophasic, this makes it go much faster.
You can alternatively react in just DCM overnight (8h)

OOPS SORRY FOR NECRO

UWe9o12jkied91dBoth NMP and DMSO are water miscible high boiling (above 200*C) solvents. DCM boils notoriously low @-40*C and toluene boils @110*C. The key is the stirring.

 

[hotelier]

why even bother cooking that shite?