Cook gone wrong

[Z420505]

So I had a company a while back send me some 5clad kit, but instead of 5bromopentene they used fluropentene and anyways it came out weak and when breaking down in acetone it just all turns white. So my ideal was to order 5bromo and more dmf and recook and hopefully come out better. Thoughts?

 

[WillD]

I think the problem is something else. The fluorinated version shouldn't be a problem.

 

[HerrHaber]

In my honest opinion I'm surprised it worked at all, and while a terminal Fluorine atom is known to work within this context Bromide at least can be a (good) leaving group but Fluoride never is, because of the C-F bond strength. The double bond is reactive in a different set of conditions therefore can't be the best reaction site. Do a small batch with 5-Bromo-1-pentene and se if the product gets any better... the turning white at contact with acetone clearly indicates that the product is different but in your optimistic view I may call it incomplete therefore the "tail" is missing as suggested by what you describe and explains a great drop in potency. You should either use 5-bromo-1-pentene or 1-bromo-5-pentANE for a more likely improvement in quality. I'm no expert in this exact field but the chemistry make's some degree of sense to me as I also find it unusual for people to describe their preparative misstakes in such a reversible manner. I think that you will end up either with better than it is potency or no significant change case in which I suggest not selling it as the problem is far from being resolved.

 

[Z420505]

It worked, the batch after recooking turned right color in solvent. Also, had a very good affect. Had a white residue at bottom but I’m going to say that was a bonding problem with first cook. 5-bromo should not be substituted with fluropentane. It’s just weak and create a different chemical that what attendended.

 

[HerrHaber]

if Fuoride was substituted as Bromide was intended to, you deserve some place in a decent journal publish about it. Instead the double bond reacted (most likely), which is also great for you and the anticipated product can't be else than potent by S.A.R. be careful with the side products though, (more potent is not necessarily more pure or safe). Cheers!

 

[Z420505]

A lot of these Chinese companies just send whatever, most are just selling without knowing exactly what they are selling. Look at the ingredients list and discovered an error in list prior to previous orders.

 

[HerrHaber]

Like one of those shops with a big advert saying "translate server error" instead the name of the shop in English

 

[HerrHaber]

I accidentally treated this as a joke when in fact it isn't that much to laugh about when knowing details of how some work as I tend not to perform any tests on my regular known materials unless something seems wrong to me.