Discussion: Alcohol & Methoxetamine

dangerous combination

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Alcohol & Methoxetamine

Alcohol, scientifically known as ethanol, affects the human body primarily by interacting with the central nervous system (CNS) and other organs. When you consume alcohol, it enters your bloodstream through the digestive system, mainly in the stomach and small intestine. Alcohol is then rapidly distributed throughout the body via the bloodstream, affecting various organs and tissues.

Alcohol is a depressant, which means it slows down the CNS. It enhances the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) and reduces the activity of the excitatory neurotransmitter glutamate.
This leads to feelings of relaxation, reduced inhibitions, and impaired cognitive and motor skills.
At lower doses, alcohol can produce a sense of euphoria and lowered anxiety.

Short-term effects of alcohol include impaired judgment, slurred speech, and reduced motor skills.
Long-term alcohol use can lead to addiction (alcoholism) and a range of health issues, including liver disease, cardiovascular problems, and neurological damage.


Methoxetamine (MXE) is a dissociative drug that affects the CNS. Its mechanisms of action are not fully understood, but it primarily works by altering the activity of neurotransmitters and receptors in the brain.

MXE primarily acts as an antagonist at N-methyl-D-aspartate (NMDA) receptors in the brain. NMDA receptors play a key role in the transmission of signals between neurons and are involved in processes like learning, memory, and pain perception. MXE's antagonistic action at these receptors disrupts normal neurotransmission, leading to dissociative and anesthetic effects.

MXE's interaction with NMDA receptors results in decreased activity of the excitatory neurotransmitter glutamate. Reduced glutamate transmission leads to altered sensory perception and can induce dissociation from one's surroundings and sense of self.

MXE may also affect the release and reuptake of neurotransmitters like serotonin and dopamine. This can lead to changes in mood, perception, and behavior, contributing to the drug's psychoactive effects.

MXE use carries risks, including impaired cognitive and motor function, hallucinations, and dissociation from reality. Excessive use or high doses can lead to adverse psychological reactions and even overdose, which may require medical attention.


Alcohol and Methoxetamine (MXE) are both substances that can affect the central nervous system, and their combination can have several significant interactions and potential dangers. Both alcohol and MXE have depressant effects on the CNS. Alcohol enhances the sedative effects of MXE, leading to increased drowsiness, dizziness, and impaired coordination with severe ataxia.

MXE can raise heart rate and blood pressure, while alcohol can have both stimulating and depressant effects on the heart. Combining these substances can lead to irregular heart rhythms and increased stress on the cardiovascular system.

Alcohol and MXE impair cognitive function independently. When combined, they can cause severe confusion, memory problems, and difficulty making decisions.

Both substances can suppress breathing, and combining them increases the risk of respiratory depression, which can be life-threatening.

In addition to the above, the combination can create conditions for:
  • Increased Risk of Overdose: The combined depressant effects of alcohol and MXE can increase the risk of overdose, which can result in unconsciousness, coma, or death.
  • Mental Health Effects: Both substances can have a negative impact on mental health, leading to anxiety, paranoia, and even hallucinations. When used together, these effects can be more pronounced.
  • Gastrointestinal Distress: Combining alcohol and MXE can irritate the stomach lining, potentially leading to nausea, vomiting, and abdominal pain.

🔴 All things considered, we recommend avoiding this combination under any conditions.
 
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