Alcohol & Pregabalin
Pregabalin is a medication employed to alleviate neuropathic pain, seizures, and social anxiety. It functions by binding to a specific type of voltage-controlled calcium channels in neurons, thereby reducing the influx of calcium into the neurons and ultimately decreasing the calcium-dependent release of certain neurotransmitters such as glutamate, norepinephrine, and substance P, resulting in a decrease in hyperactive neurons.
Furthermore, Pregabalin increases the activity of the decarboxylase enzyme, which converts glutamate into GABA, thereby increasing GABA concentrations. Continued use of Pregabalin also increases the concentration of GABA transporter proteins, thereby increasing the rate of GABA transportation.
Alcohol and Pregabalin are both central nervous system depressants, which slow down brain activity and can cause drowsiness, sedation, and impaired coordination and judgment. When used together, the effects of these two substances can be addictive, increasing the risk of side effects and dangerous interactions, including a higher risk of accidents and injuries, as well as the possibility of respiratory depression.
Additionally, alcohol can increase the risk of specific side effects of Pregabalin, such as dizziness, confusion, and blurred vision, and may lead to an increased risk of seizures.
Pregabalin also significantly enhances the effects of alcohol and causes a general increase in euphoria. Achieving balance can be difficult, even when rules and dosages are followed, with consumers likely to experience unpleasant side effects such as problems with coordination, memory loss, a hard hangover, and the feeling of buzzing all over the skull.
It is important to note that the combination of Alcohol and Pregabalin, over time, will increase the chances of developing a strong resistant addiction.
Despite this, Pregabalin is also used with some success to combat alcoholism. Studies indicate that individuals who suffered from alcohol but observed sobriety and took Pregabalin in dosages of 150-450 mg/day experienced fewer relapses and abstained from drinking alcohol for longer.
Given this, it is recommended to keep in mind the side effects that can be dangerous and weigh the risks before considering the combination of Alcohol and Pregabalin.
Last edited by a moderator: