Injectable opiates & MDMA
Injectable Opiates, including morphine, heroin, and synthetic opioids like fentanyl, primarily act on the opioid receptors (mu, delta, kappa) in the brain and nervous system. By activating these receptors, opiates mimic the effects of endogenous opioids (endorphins), leading to analgesia (pain relief), euphoria, and sedation. They also depress the central nervous system (CNS), reducing respiration, heart rate, and blood pressure.
MDMA is a psychoactive substance that enhances serotonin, dopamine, and norepinephrine release and inhibits their reuptake. It primarily affects the serotonin system, leading to increased mood, empathy, and energy. MDMA also has stimulant properties due to its effects on dopamine and norepinephrine.
Combination of Injectable Opiates and MDMA.
MDMA increases the risk of dehydration and hyperthermia, which opiates may exacerbate by dulling the body's natural responses to overheating and fluid loss.
Opiates suppress respiratory function, and combined with MDMA, which can increase physical activity and elevate body temperature, this can lead to unpredictable respiratory issues.
MDMA's stimulant effects can increase heart rate and blood pressure, which, when combined with opiates, can strain the cardiovascular system, especially in individuals with underlying health conditions.
Combining this substance increases the risk of overdose, as users may not accurately judge the potency or effects of the combined substances.
Some users report enhanced euphoria and a more profound sensory experience when combining opiates with MDMA. However, the risks and side effects significantly outweigh these. In addition, the mechanisms of action of substances are opposite to each other (Opioids are depressants, MDMA is a stimulant by the general nature of action). In such a scenario, the stress on physiological systems and the psyche will always be high. Without experience with the substances individually and understanding the risks, this combination will be dangerous.
Although we are talking about injectable opioids now, it is worth noting that some tableted substances of this class (Tramadol) lower the threshold of seizures, which in combination with MDMA can cause an attack in a certain group of people.
There is also limited research evidence that frequent exposure to MDMA can, at the biochemical level, alter the sensitivity of certain brain structures to the opioid reward system. This moment needs further research.
Considering the above, we recommend treating this combination with great caution.
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