Psilocybins & Dextromethorphan (DXM)
Psilocybin, the active compound in Psilocybin mushrooms, is converted in the body to psilocin. Psilocin primarily acts as an agonist at serotonin (5-HT) receptors, particularly the 5-HT2A subtype. This action is thought to underlie its psychedelic effects. Psilocin also affects other neurotransmitter systems but to a lesser extent. These include altered perception of reality, visual and auditory hallucinations, and changes in thought, mood, and consciousness. Physiologically, it can cause pupil dilation, increased heart rate, and blood pressure.
Common adverse effects include nausea, headache, and disorientation. It can also induce psychological distress and exacerbate underlying psychiatric conditions, notably psychosis.
Dextromethorphan (DXM) is a dissociative anesthetic, primarily acting as an NMDA receptor antagonist. It also affects other systems, including the serotonin and norepinephrine transporters, and has sigma-1 receptor agonist activity. At therapeutic doses, DXM acts as a cough suppressant. At higher doses, it produces dissociative, euphoric, and hallucinogenic effects.
Adverse effects include dizziness, nausea, and motor control disturbances, and in high doses, it can lead to dissociative states, hallucinations, and serotonin syndrome.
The combination of Psilocybin mushrooms and DXM involves complex pharmacological interactions due to their distinct mechanisms of action. It can lead to unpredictable and potentiated effects. The risk of serotonin syndrome, a potentially life-threatening condition, is notably increased due to the serotonergic activity of both substances.
Both substances being hallucinogens, their combination can intensify hallucinations and sensory distortions. This can lead to more profound psychological experiences but also increases the risk of negative effects like panic attacks, confusion, frightening hallucinations (often referred to as a "bad trip"), and psychosis.
There could be compounded effects on heart rate, blood pressure, and motor control, leading to increased risks of physical harm.
The combined effects on the brain's neurotransmitter systems can be unpredictable, possibly leading to neurotoxic effects or exacerbation of psychiatric symptoms.
While some can report benefits from this combination, such as intensified experiences or spiritual insights, the risks associated with combining these substances are significant and multifaceted. They include acute physiological risks, the potential for severe psychological distress, and unpredictable interactions at the neurotransmitter level. It is crucial to approach such combinations with caution and awareness of the potential dangers, especially in individuals with pre-existing mental health conditions.
We have not come across confirmed data on acute fatal conditions associated with this combination. However, the intensity of the effects and the nature of the action of both substances separately give an understanding that this combination as a whole is meaningless for a general public. But if you have sufficient experience, knowledge and desire for radical experiments, then we can only wish you good luck in your travel. Don't forget to describe your experience in the comments, it can be useful for the community.
Considering the above, we recommend treating this combination with great caution.
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