Mephedrone and Alcohol
The combination of these substances has two main scenarios.
1. First alcohol, then mephedrone. This also includes simultaneous intake of substances.
In this scenario, alcohol acts as a base substance, and mephedrone allows you to achieve several goals:
a) to remove the excess effect of alcohol - to sober up, clear your mind.
b) add strong euphoria and sensitivity to the effect of alcohol. Psychostimulating effects are not only enhanced, but also proven to last a little longer (3 hours instead of 1-2 hours in the experiment).
In both variations (a, b), after starting to use mephedrone, it`s not worth continuing to drink alcohol. There is a possibility of accidental overdose. Mephedrone will reduce the subjective effects of alcohol, which we use to assess our condition. However, the physiological effect of alcohol will not go away.
If, after alcohol intoxication, the effect of mephedrone is applied and you continue to drink alcohol, then after the end of the action of the euphostimulator (mephedrone has a two times shorter half-life than alcohol), the body will face massive amounts of ethanol and its processed products, which will lead to increased disinhibition, problems with movement control, depression of consciousness, breathing and other troubles. Therefore, it is important to remember that the feeling of sobriety after mephedrone does not give the green light to continue the banquet.
2. First mephedrone, then alcohol.
In this scenario, mephedrone is the base substance, and alcohol plays the role of sedative, which helps to finish the session and fall asleep. In theory, this is quite a working scheme if, after mephedrone, a person drinks a little weak or even less strong alcohol.
However, often the long-awaited sleep and peace do not come, a person in pursuit of peace drinks an excessive amount of alcohol. And, roughly speaking, alcohol intoxication and the hangover following it are sharply added to the loads and post-effects of mephedrone (its pharmacokinetics does not change in this combination).
If you go this way, you should focus on 1-2 small bottles \ cans of beer, 1-2 glasses of wine, 1-2 shots of strong alcohol. The larger the portion and the stronger the alcohol, the higher the chances of experiencing tachycardia, high blood pressure, headache and mega hangover in the morning.
Pitfalls for both scenarios:
1) Mephedrone and alcohol often potentiate amnesia during the session. The entire session may fall out of memory. It`s difficult to do anything about these, except to avoid combinations if you have encountered palimpsests and this is unacceptable for you.
2) Both substances decently consume water reserves in the body, and their combination enhances this effect. Dehydration often leads to loss of electrolytes, general poor health, increases the risk of fainting and seizures. During the session, it`s worth taking water in small portions, preferably mineralized and without gas.
3) This combination in studies increased the pulse rate to a greater extent than a single dose of mephedrone.
4) Frequent combination of mephedrone and alcohol implies higher risks of abuse and combined dependence on substances than taking them separately.
Timing.
Experimental data on men with an average age of 28 years showed:
For a dosage of 200 mg of mephedrone and 0.8 g / kg of alcohol, cardiovascular and subjective effects after simultaneous administration of mephedrone and alcohol began in 0.25-5 hours, peaked about 0.75–1.5 hours after administration and returned to the values before the dose in 4-8 hours after administration with about 3-4 hours of pronounced effects.
Link to the study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999687/
And as always, combinations of psychoactive substances require experience and compliance with dosages. For a combination, use half of the usual doses for substances separately.
The combination of these substances has two main scenarios.
1. First alcohol, then mephedrone. This also includes simultaneous intake of substances.
In this scenario, alcohol acts as a base substance, and mephedrone allows you to achieve several goals:
a) to remove the excess effect of alcohol - to sober up, clear your mind.
b) add strong euphoria and sensitivity to the effect of alcohol. Psychostimulating effects are not only enhanced, but also proven to last a little longer (3 hours instead of 1-2 hours in the experiment).
In both variations (a, b), after starting to use mephedrone, it`s not worth continuing to drink alcohol. There is a possibility of accidental overdose. Mephedrone will reduce the subjective effects of alcohol, which we use to assess our condition. However, the physiological effect of alcohol will not go away.
If, after alcohol intoxication, the effect of mephedrone is applied and you continue to drink alcohol, then after the end of the action of the euphostimulator (mephedrone has a two times shorter half-life than alcohol), the body will face massive amounts of ethanol and its processed products, which will lead to increased disinhibition, problems with movement control, depression of consciousness, breathing and other troubles. Therefore, it is important to remember that the feeling of sobriety after mephedrone does not give the green light to continue the banquet.
2. First mephedrone, then alcohol.
In this scenario, mephedrone is the base substance, and alcohol plays the role of sedative, which helps to finish the session and fall asleep. In theory, this is quite a working scheme if, after mephedrone, a person drinks a little weak or even less strong alcohol.
However, often the long-awaited sleep and peace do not come, a person in pursuit of peace drinks an excessive amount of alcohol. And, roughly speaking, alcohol intoxication and the hangover following it are sharply added to the loads and post-effects of mephedrone (its pharmacokinetics does not change in this combination).
If you go this way, you should focus on 1-2 small bottles \ cans of beer, 1-2 glasses of wine, 1-2 shots of strong alcohol. The larger the portion and the stronger the alcohol, the higher the chances of experiencing tachycardia, high blood pressure, headache and mega hangover in the morning.
Pitfalls for both scenarios:
1) Mephedrone and alcohol often potentiate amnesia during the session. The entire session may fall out of memory. It`s difficult to do anything about these, except to avoid combinations if you have encountered palimpsests and this is unacceptable for you.
2) Both substances decently consume water reserves in the body, and their combination enhances this effect. Dehydration often leads to loss of electrolytes, general poor health, increases the risk of fainting and seizures. During the session, it`s worth taking water in small portions, preferably mineralized and without gas.
3) This combination in studies increased the pulse rate to a greater extent than a single dose of mephedrone.
4) Frequent combination of mephedrone and alcohol implies higher risks of abuse and combined dependence on substances than taking them separately.
Timing.
Experimental data on men with an average age of 28 years showed:
For a dosage of 200 mg of mephedrone and 0.8 g / kg of alcohol, cardiovascular and subjective effects after simultaneous administration of mephedrone and alcohol began in 0.25-5 hours, peaked about 0.75–1.5 hours after administration and returned to the values before the dose in 4-8 hours after administration with about 3-4 hours of pronounced effects.
Link to the study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999687/
And as always, combinations of psychoactive substances require experience and compliance with dosages. For a combination, use half of the usual doses for substances separately.
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