How to synthesis 4 piperidone monohydrate hydrochloride ?

[madmaximus]

Can someone share how to synthesis this chem

 

[G.Patton]

It's worth to buy than synthesize

 

[woohoo]

If you need 4-piperidone itself, not ANPP or NPP, you probably will be able to do it only by N-benzyl amine route through acrylates. And later removing benzyl by hydrogenation on palladium.
I think, easier routes should be known.
Maybe it possible to make boc salt of pyridine derivate like anilino pyridine and reduce it with nabh4.
Like there: https://www.hbyingong.com/wholesale...dine-raw-powder-in-stock-cas-125541-22-2.html

I have a questions about it all:
1.Can i use butyl acrylate instead of methyl or ethyl for condensation?

2.Is it possible make piperidone via pyridine salts reduction, like in arecoline synthesis from nicotinic acid?

3.What the industrial route for not substituted 4-piperidone?

I'm not interested in making this shit in large amounts, because all world and united states very angry on fent dealers.
And i don't support opioid epidemic with this ridiculous abuse, when you need it every hour and selling your car to buy more.
Just want something weak like furanyl, butyryl, acetyl for my own stash.

 

[woohoo]

If you need 4-piperidone itself, not ANPP or NPP, you probably will be able to do it only by N-benzyl amine route through acrylates. And later removing benzyl by hydrogenation on palladium.
I think, easier routes should be known.
Maybe it possible to make boc salt of pyridine derivate like anilino pyridine and reduce it with nabh4.
Like there: https://www.hbyingong.com/wholesale...dine-raw-powder-in-stock-cas-125541-22-2.html

I have a questions about it all:
1.Can i use butyl acrylate instead of methyl or ethyl for condensation?

2.Is it possible make piperidone via pyridine salts reduction, like in arecoline synthesis from nicotinic acid?

3.What the industrial route for not substituted 4-piperidone?

I'm not interested in making this shit in large amounts, because all world and united states very angry on fent dealers.
And i don't support opioid epidemic with this ridiculous abuse, when you need it every hour and selling your car to buy more.
Just want something weak like furanyl, butyryl, acetyl for my own stash.

woohooup the questions

 

[G.Patton]

up the questions

woohooLearn this

 

[woohoo]

double posted

 

[woohoo]

Learn this

G.Patton
This reaction isn't used for required piperidone, maybe because of self condensation and mix of products, when formaldehyde used instead of benzaldehyde, steric hindrance is important too.
I saw many papers, and piperidones or 4-substituted piperidines was made through: acrylates, organosilicon compounds, unsaturated compounds (oxidized to divinyl ketone derivate) or pyridine salts.

Maybe, synthesis of divinyl ketone via mannich reaction is a possible way. i'll check patents.