Mescaline 3,4,5-trimethoxyphenyl-2-nitroethane

[Octopusssss]

Hello

I found realy easy mescaline synthesis.

3,4,5-Trimethoxy-beta-Nitrostyrene and 3,4,5-Trimethoxyphenyl-2-Nitroethane

I make all the steps and the final product is 3,4,5-trimethoxyphenyl-1-nitroethane as it is in the end of synthesis document or it is 3,4,5-trimethoxyphenyl-2-nitroethane as it is in the title of the document.

Than i took 300mg and after 1 hour i sleept realy nice and about 3 hours later i took another 300mg and i felt nothink.

Can You please tell me if the decomposition of product is so fast or the product made by this document is not yet the mescaline....

I am wondering whats wrong hiere because all proces is realy easy going and final product looks like on photos.

Please help

 

[Octopusssss]

I can also add that product checked by marquidse reagent is orange as mescaline should be.

 

[G.Patton]

I can also add that product checked by marquidse reagent is orange as mescaline should be.

Mango2cbHello. You produced 3,4,5-trimethoxyphenyl-2-nitroethane, which is precursor of Mescaline. Read about Mescaline here. It is the reason why you didn't get any effects of Mescaline (different substances).

 

[Octopusssss]

Hello. You produced 3,4,5-trimethoxyphenyl-2-nitroethane, which is precursor of Mescaline. Read about Mescaline here. It is the reason why you didn't get any effects of Mescaline (different substances).

G.PattonThank You i understand now. Its not reducted. I didnt found any article or document about mescaline from 3,4,5-trimethoxyphenyl-2-nitroethane but there is plenyty about it from 3,4,5-trimethoxy-beta-nitrostyrene so i will go this way...

http://bbzzzsvqcrqtki6umym6itiixfhni37ybtt7mkbjyxn2pgllzxf2qgyd.onion/threads/synthesis-of-mescaline-with-nitromethane-1000g-scale.76/

I will report if there will be succes . Dont worry G. Patton - i made it for science

 

[Octopusssss]

But also only this information i was able to find on internet:

1-(3,4,5-trimethoxy)phenyl-2-nitroethane - The Indole Shop

1-(3,4,5-trimethoxy)phenyl-2-nitroethane, Buy P2NP, buy phenyl 2 nitropropene, dimethoxynitrostyrene. There is no known information on its pharmacology.This compound is NOT for human consumption and is available strictly for research purposes only.

theindoleshop.com

Mescaline-dihydronitrostyrene, aka 1-(3,4,5-trimethoxy)phenyl-2-nitroethane, is a chemical derivative of 3,4,5-trimethoxy-beta-nitrostyrene. It is a product of partially reducing mescaline-nitrostyrene (3,4,5-trimethoxy-beta-nitrostyrene) with sodium borohydride. It is closer in chemical structure to mescaline, and the C=C double bond on the nitrostyrene is already reduced into a saturated C-C single bond. Therefore less chemical energy is required to reduce the nitro group into an amine.

Research has shown that nitroalkanes (such as mescaline-dihydronitrostyrene) can theoretically be reduced into amines using sodium dithionite (a common reducing agent in the wood-making process) and a PTC (phase-transfer catalyst), such as octylviologen [1]. Other PTCs in lieu of octylviologen can be used, such as quaternary amine salts.

So maybe there is easy way to convert 3,4,5-trimethoxyphenyl-2-nitroethane to mescaline - but i cannot find how to do it...

 

[Octopusssss]

G. Patton if i will find the way to change Mescaline-dihydronitrostyrene in mescaline i will post hiere - i am working on it - this way can be realy easy if i will find the way - for small scale.
I also found way to make the large scale mescaline synthesis more easy and i post in in hiere:

http://bbzzzsvqcrqtki6umym6itiixfhni37ybtt7mkbjyxn2pgllzxf2qgyd.onion/threads/synthesis-of-mescaline-with-nitromethane-1000g-scale.76/

 

[Octopusssss]

Ok i have to way to turn Mescaline-dihydronitrostyrene, aka 1-(3,4,5-trimethoxy)phenyl-2-nitroethane into mescaline:

1. Solution IPA/H2O 2:1 (18 liters) was added to the reactor.
2. NaBH4 (1200 g) was added at once and stirring was started.
3. Mescaline-dihydronitrostyrene, aka 1-(3,4,5-trimethoxy)phenyl-2-nitroethane = (1000 g) was added in small portions so that the temperature of the mixture did not exceed 60 *С.
4. CuCl2 (72 g) in water (200 ml) was added slow dropwise so that the temperature of the mixture did not exceed 80 *С.
5. Thereafter, reaction was then held at 80 °C for 30 minutes using external heating (i didnt do this step in my case because precursor was almost ready to change)
6. 25% water solution of NaOH (8 liters) was added to reaction mixture and the phases were separated.
7. The aqueous phase was extracted with 8 liters IPA

Let the layers separate - leave it for some time. Take uper layer. Whats left can be extracted by ading IPA. Than we can put uper layer and IPA from washing together.

8. We will add 30% H2SO4 to the yellow liquid from point 7. We do it drop by drop with stiring that the PH will go to PH 6. Drop by drop slowly. Than we can see that this starts to be milky and we can see cristals. We can leave it in fridge (i dont know if this will help) and than we filter it.

9. We are left with mescaline sulftae dihydrate. Its nice white and we can wash it with aceton in we want. Its (C11H17NO3)2 x H2SO4 x 2H2O

This make easy - we dont need vacum...

 

[G.Patton]

Let the layers separate - leave it for some time. Take uper layer. Whats left can be extracted by ading IPA. Than we can put uper layer and IPA from washing together.

8. We will add 30% H2SO4 to the yellow liquid from point 7. We do it drop by drop with stiring that the PH will go to PH 6. Drop by drop slowly. Than we can see that this starts to be milky and we can see cristals. We can leave it in fridge (i dont know if this will help) and than we filter it.

9. We are left with mescaline sulftae dihydrate. Its nice white and we can wash it with aceton in we want. Its (C11H17NO3)2 x H2SO4 x 2H2O

This make easy - we dont need vacum...

Mango2cbI've answered to you in Mescaline topic. Do not multiply same messages in different topics please.