Replacing CuCl2 with sulphate?

[MadHatter]

In the NaBH4 reduction of P2NP to amphetamine, can CuCl2 be substituted for CuSO4? Or do the sulphate ions interfere?

 

[T0lek511]

Yes it can be. The reduction its provided by Cu(II) ion.

 

[HerrHaber]

Confirmed, you must take into account the molarity of the aqueous solution and the water of crystalization which is 5 water molecules per CuSO4 molecule when talking about the blue crystals which are the more common form with a molar mass of 249,28 g/mole including the five moles of water in it. You should prepare the solution with the same molarity as the nitrate or chloride in the procedure.