Resort Method for synthesizing (R) - (1-phenethyl) -1H-imidazole-5-carboxylic ester/Etomidate

tianwangmimi

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I manufactured etomidate using the method described in patent number CN114456118A, but I used his example method and none of them were successful. In the first step, I perfectly obtained the product, but in the second step, I was unable to obtain what I wanted. In addition, I have also tried the example step in patent number US3354173A, but it still fails. There are too many magazines, and the target product yield is less than 15%.

I have never understood why, so I am here to see if I can find an answer. Thank you.
 

Killer Fable

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Chinese patents are all fake
 
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