Syntéza 4'-methylpropiofenonu z toluenu Friedelovou-Craftsovou reakcí (měřítko 1 kg+)

[Deedubbau]

Pan Bezpečnost na záchranu....

Ano, raději se ujistěte, že máte na sobě všechny ochranné pomůcky. Protože pokud se budete řídit touto radou a použijete nerezovou ocel, budete mít na krku katastrofu. Nerez rychle napadají organické kyseliny a chloridy. Takže jakmile tuto směs zahřejete, raději se připravte na běh....nebo prostě zůstaňte u skla.

 

[amieri]

"let me show you something"

 

[NovicechemistEU]

Tomorrow I'm starting the big day synthesis with a small batch.
I wanted to start with a small batch for my first try.
1.08 mol 100 Gr 95.2 mL propionyl chloride
1.12 mol 150 Gr: AlCl₃
2.81 mol 300 ml 261 Gr Toluene
I can use 50 ml more toluene. 350 ml
Toluene of 99.5% purity was dried and then distilled under vacuum. We follow the advice of the masters

 

[William D.]

Do not forget to pour it into cold water. Not water into the reaction mixture. This is very important.

 

[Smokesalot99]

Can you replace propionyl chloride with propionic anhydride for reaction?

 

[The-Hive]

try it and let us no do it on a small scale then compare it to using propionyl chloride

 

[William D.]

Do you think this reagent is more easy to buy? And cheaper? I think this is not so, but if you have it, you can go with such a route but with correction.

 

[NovicechemistEU]

I finally managed to make the synthesis, I can't thank @William D. enough for helping me every step of the way, I am very grateful
Now I just need to distill the dirty 4'-methylpropiophenone under vacuum