Aaaargh, you beat me to it.
But there are other routes starting with other materials. Often times the starting material will be something like toluene and methyl anthranilate or phtalic anhydride. Or even vinyl gloves.
I think the most elegant OTC route to this synth is toluene and methyl anthranilate.
Toluene to be treated with nitrating mixture of sulphuric acid/nitric acid to yield racemic nitrotoluene, which is then easily separated through freezing points yielding o-nitrotoluene. The o-nitrotoluene is then refluxed over tin with addition of HCl to yield o-toluidine.
The methyl anthranilate is available as a fragrance/taste chemical from diverse vendors in the perfume industry. It can be demethylated easily through treatment with NaOH to yield anthranilic acid, which can then be used together with the o-toluidine.
The problem with this drug is the high doses needed to achieve effect. A normal dose is around 400 mg, which makes it difficult to break even. Also, the workups a bitch, honestly, It's really difficult to achieve a pure, white end product.
But there are other routes starting with other materials. Often times the starting material will be something like toluene and methyl anthranilate or phtalic anhydride. Or even vinyl gloves.
I think the most elegant OTC route to this synth is toluene and methyl anthranilate.
Toluene to be treated with nitrating mixture of sulphuric acid/nitric acid to yield racemic nitrotoluene, which is then easily separated through freezing points yielding o-nitrotoluene. The o-nitrotoluene is then refluxed over tin with addition of HCl to yield o-toluidine.
The methyl anthranilate is available as a fragrance/taste chemical from diverse vendors in the perfume industry. It can be demethylated easily through treatment with NaOH to yield anthranilic acid, which can then be used together with the o-toluidine.
The problem with this drug is the high doses needed to achieve effect. A normal dose is around 400 mg, which makes it difficult to break even. Also, the workups a bitch, honestly, It's really difficult to achieve a pure, white end product.
