There was a alternative for mechanical stirrer?
One Alternative would be strong magnetic stirrer although the large ones are pretty pricy and it would be more cost effective to buy a mechanical one.
Synthesis of 4'-methylpropiophenone from toluene by Friedel-Crafts reaction (1kg+ scale)
- Thread starter William Dampier
- Start date
Mr. Safety to the rescue....
Yeah you better make sure you are wearing all that protective gear. Cause if you take this advise and use stainless steel you are going to have a disaster on your hands. Stainless is rapidly attacked by organic acids, and chlorides. So once you warm this mix up you better be prepared to run....or just stick with glass
- By The-Hive
I use stainless steel vessel for larger reactions so far so good IMO
- By waltjr5858
Yeah but for this exact reaction we're talking you're doing something extremely dangerous using metal. You don't need all that crap and first of all just because they're doing a large reaction doesn't mean someone else is the mechanical steerer is absolutely not needed and a stir bar is perfectly fine. Use glass only for anything to do with acids. You also don't need all that gear. Little out of control looking like you're cleaning up radioactive spill.
- By waltjr5858
You should actually probably delete that comment somehow or a mod should because if anyone reads that and does it they're actually putting themselves in danger. Anyone that deals with chemistry on a normal basis should absolutely know that you wouldn't use a stainless steel reaction vessel for that I actually kind of laughed a little bit
hello, can toluene be replaced with xylene?
- By plancklong
No. The toluene is not just the solvent. It is the basis for the 4-methylpropiophenone:
Which xylene did you have in mind, o, m, or p? Never mind, it's probably a mixture of all 3:
If you did use these, can you see that you would NOT be synthesizing 4-methylpropiophenone?
Which xylene did you have in mind, o, m, or p? Never mind, it's probably a mixture of all 3:
If you did use these, can you see that you would NOT be synthesizing 4-methylpropiophenone?
You could synthesise toluene from xylene by hydrogenation although toluene is pretty easy to source therefore doing this isn’t that practical.
Does it mean I don't heat? Don't you think it will take a long time to completely evaporate?
Thank you for your opinion and advice
Thank you for your opinion and advice
Yes, it's possible, toluene evaporates quite fast even at RT.
You can also heat gently on a water bath
You can also heat gently on a water bath
I remember when I hive bee done it in 2003 he used
73g aluminium chloride
300mL dichloroethane
46mL propionyl chloride
54mL toluene
600mL iced water
200mL 5% NaOH solution
Magnesium sulfate
73g aluminium chloride
300mL dichloroethane
46mL propionyl chloride
54mL toluene
600mL iced water
200mL 5% NaOH solution
Magnesium sulfate
I couldn't find it either. I searched 4-methylpropriophenone and 5 other names for it
- By The-Hive
54mL (500mmol, 46g) toluene was added over 30 minutes to a solution of 73g (550mmol) anhydrous aluminium chloride and 46mL (525mmol, 49g) propionyl chloride in 200ml dichloroethane cooled via an external ice bath. The solution was allowed to stir for a further 1.5 hours at 20oC, and was then carefully added to 500mL stirred iced water. The lower dichloroethane layer was separated off, and the aqueous layer extracted with 2x50mL dichloroethane. The combined extracts were washed with 2x100mL 5% NaOH, 100ml water, and then dried over magnesium sulfate. The solvent was removed, and the ketone vacuum distilled at 123-126oC
dichloroethane. Can't sub it, it's the hydrocarbon backbone(well maybe another halogenated ethane). A fair bit of pain in the ass chems. I hope to go a little more OTC. This could be done by me, the workup is just excessive for where I live (no 190 proof everclear golden -grains. No propoinyl chloride without a license ).
I've got the one I plan to go with. I certainly don't mind reading some more but.... What I aught to do is build a 
and go straight from propoinyl chloride I hope to synth and toluene to 4-mp at 105 psi. 7 atmospheres 
buying chemicals is my cryptonite. Finding references is my superpower. Later, I heard someone was making tartaric acid from cream of tartar and HCl. They can't believe people would buy it
I've came across at least 10 routes to 4 mp
and go straight from propoinyl chloride I hope to synth and toluene to 4-mp at 105 psi. 7 atmospheres buying chemicals is my cryptonite. Finding references is my superpower. Later, I heard someone was making tartaric acid from cream of tartar and HCl. They can't believe people would buy itI've came across at least 10 routes to 4 mp
