Synthesis of Amphetamine from P2NP via SnCl2 and Zn

[Bigballen]

How much desired acid to add at the end?

 

[blacky2340]

Pour 10ml acetone onto 1ml concentrated 97%+ sulfuric acid 10:1 ratio. Use pipette or syringe to drop the solution slowly until pH 5.5 is reached. If overacidified, add more freebase, if way overacidified and turns into liquid then to a/b and recryistalize.

 

[ActionAyi]

I have thought about toulene too but i think the difference of density is too low isnt it ?

 

[G.Patton]

Hello, thank you for your report! It's really interesting. 10g of amph free base is 80.4% yield, quite good. How much salt did you get?

 

[Eleusius_hive_reboot]

i just did this synthesis successfully ! (i was very astonished, that it works, like described...!)

i used 1,7g P2NP

- created sncl2 sol. from h202 and conc HCL first, until total dissolution, quenched oxidizing agent w. Bisulfite.

- dissolved p2np in acetone / EtoH and brought solutions of sncl2/p2np-solvent together in 250ml RBF

vigourously stirred for 2hrs.

------SKIPPED OXIME ISOLATION !!!!! -----

instead gave antoher dash of conc. HCL in to the whole

and gave finely divided active-C powder a hydrogen absorber in to RM.

then three portions of Zn-dust were introduced in several heaps...with subsequent hcl/EtoH addition.

as the reagents were used up i gave a small am. of AcOH to the whole and let it further react out a 15mins.


- now i slowly alkalized to ph 12 (metal precipitates formed immediate and sank...no hassle in base extraction....did with xylene/pet.ether/naphta mixture (+a small emulsion preventing splash of 2-propanol , every extraction step...)


i pooled organic xtracts, washed them with conc.brine f. rocksalt....)

afterwards the washed org.phases were run trough fine filtering apparatus.

added a 100mls of H20 and then titrated with Hcl until ph 5,5 ~


the acidic solution was equiv. mixed with acetone / ethanol-2propanol

with concentration under stirring with surface vent.

then the pasty residue was further refined...

I OBTAINED almost 1,3g amph-hcl (hygroscopic but useable!)

so that is a fine well thought route to go, THANKS TO ORIGINAL MASTERMIND

 

[Eleusius_hive_reboot]

* MAJOR ! update:...

I DID ONE MORE "GOD-MOVE" AFTER THIS SURPRISE RESULT:.....

I SUCCEEDED IN MODIFYING THE SYNTHESIS - AND DID A REDUCTIVE AMINATION

WITH REFINED P2P AND METHYLAMMONIUMACETATE (OR KIND OF)

IT YIELDED METHAMPHETAMINE RACEMATE.... VERY UNEXPECTED QUANTITY- QUALITY AS SAME AS THE USUAL NABH4 ROUTE I PREFERRED BEFORE...


IT WENT DOWN FROM Imine formation -[ACIDIFIED VARIANT]...... TO HYDROCHLORIDE OF SLIGHT PINK APPEARANCE OVER NIGHT !

-->AT ROOM TEMPERATURE<----

PLEASE dont be mad at me but i decided to keep specifics for myself**

it is a whole new approach to phenetylamine syntheses in general ....

CREDITS TO THIS COMMUNITY PRO INSTRUCTIONAL P2P PURIFICATION TUTORIALS / I WENT TROUGH THE HASSLE OF THE WHOLE WORKUP TECHNIQUES OF THE BB-gate wisdom ...

THE PHENYLACETONE I DERIVED BY : Fe/H+ --P2NP---> Phenyl-2-Propanone


**(exception 4 you, Patton ..i made a writeup , documenting specs etc. i think you get what these
synthesis-dynamic principles hold in value )

 

[TucoSalamanca.]

I got 5 grams of amphetamine from 15 grams of p2np.​

 

[Chemdogkm]

u recomend this reaction? Or the aluminum? Or the copper?

 

[sandman]

I don't think this works. I hope it does and will have to try it.

 

[TucoSalamanca.]

I hope you succeed, mate, I failed.

 

[TucoSalamanca.]

Have you done this method

 

[mithyl2]

I've done the borohydride method many times with no success. the closest i came was making about 0.2% yield of amphetamine. it was real though. i need this to work very badly, and it's driving me absolutely mad. let us know how the dcm goes.

 

[TucoSalamanca.]

I will write, my friend, do not miss your prayers so that this synthesis can be realised, thank you.

 

[TucoSalamanca.]

I couldn't synthesise today, I'll do it tomorrow and report back.

 

[ActionAyi]

is there any other way for extract than DCM ?
Maybe n-Hexane ?

 

[August]

Hello friends, does this reaction not just produce phenylethylamine (PEA) or am I just dumb (strong possibility)

 

[William D.]

Part of this method allows you to get phenylacetone. But stage 2 can be difficult.

 

[Amin. M]

Hello my friend
I read your comment and enjoyed it
How did you get pure amphetamine (in the second step)?
Please advise which method of producing amphetamine is better and ultimately has a higher percentage of purity
And that he procured the raw materials through the store
(I don't have a professional laboratory)

 

[michelAMPH]

Zonder de kosten van 300 gram P2NP .
alle grondstoffen voor 200 gram amfetamine free base kosten hier €416,68???
Mooi recept alleen het kan totaal niet uit