Amphetamine purification by acid-base extraction

[G.Patton]

Yes, you'll get amph phosphate.

 

[ASheSChem]

Finaly i have try; but nor reaction on my flask

no milky cloud appeared in my flask

 

[G.Patton]

Have you added the acid directly to amph free base?

 

[ASheSChem]

No i have try an acétone mix like 10:1

 

[G.Patton]

It's too much, man. 1:2 or 1:3 free base:acetone is okay.

 

[ASheSChem]

Next Time i'll try that

 

[Berlin777]

once I tried this method but while adding NaOH solution white precipitate showed up so I was unable to rebase it

 

[Jimmyjohn48]

Seen similar happen. What was the cause

 

[rabbitass]

does it refer to something like that? the phases were not separated

 

[Berlin777]

Yeah something like this, I was expecting to have a oil but I couldn’t see any apart of the solids

 

[rabbitass]

does it refer to something like that? the phases were not separated
Isn't it amphetamine?

 

[G.Patton]

Hi, can you tell me please, at what step exactly it formed?

 

[rabbitass]

I dissolved amphetamine 1:1 in water, I had to add a little more water to dissolve everything. The water had a pH of 1. I added drops of water with NaOH until I had a pH of 12. That's where that kind of white mass was formed.

 

[G.Patton]

It's salt of an adulterant, which your amphetamine has. Amphetamine salt can't make pH 1 at water. It's an acid. After addition NaOH, this acid formed insoluble salt with Na. You can filter it.

 

[rabbitass]

Can I use toluene as a solvent instead of DCM or Diethyl Ether? It is impossible for me to get any of those 2 solvents.


No oil was formed, did you filter the water to remove the solid and then try to extract the amphetamine from the water?

Sorry for asking so much, I'm trying to find out everything I can through my means but the information is limited.

 

[G.Patton]

Hi, don't be sorry.
Yes, you can use toluene.
Yes, procedures are correct. But it seems that there is no amphetamine.

 

[rabbitass]

@G.Patton Why weren't the phases separated? They look like fiberglass but the oil wasn't made.

 

[kitboy]

What is the solid that is formed when amphetamine is dissolved in water? when heated if it dissolves in water

 

[William Dampier]

If you dissolve salt, then it just dissolves. You can get salt back, crystallizing in water with cold or evaporating water