2C-fenüületüülamiinide sünteesid

[NarwhalFucker419]

Kas kellelgi on infot 2C-H bromimise kohta n-bromosuktsinimiidiga? Olen näinud, et mõned inimesed on seda mujal maininud, kuid ei ole leidnud ühtegi kirjutist.

 

[Raxmil]

Otsin ka seda, kuid ma ei suutnud leida üksikasjalikku teavet
Mida ma tean, on see, et seda saab teha GAA-s või DCM-s, kuid ei tea, milline on suhe

 

[amieri]

There's a person in maybe theehive on Reddit.i believe the also have a mescaline synth posted too and a few others.

 

[btcboss2022]

Mul on kahtlus 2CB sünteesi viimase etapi suhtes. Seal öeldakse: "Reaktsioonisegul lubati naasta toatemperatuurile, filtreeriti ja tahked ained pesti säästlikult külma äädikhappega", kuni ma tean, et äädikhape muutub tahkeks 16-17C juures, nii et mida tähendab külm äädikhape täpselt?
Tänud.

 

[G.Patton]

Tere. Ma eeldan, et külm hape tähendab toatemperatuuri, sest seal on selgitus, et reaktsiooni käigus eraldub soojust.

 

[btcboss2022]

Ok ok ma arvasin ka seda, aga eelistasin kinnitada, sest nagu te teate, kui me ütleme külm tavaliselt mõtleme sügavkülmast mitte RT hahaha aga äädikhappe puhul ei ole võimalik ;-) tänud

 

[w2x3f5]

Ma ei saa päris hästi aru, miks peseb amiinhüdrobromiidi, seda ei saa kasutada, see põleb. Parem on puhastada ja saada hüdrokloriidi ja kaod on väiksemad, kui vältida kahtlasi katseid pesta pulbrit bromist.

 

[nujrc]

Ma saan aru, et järelejäänud elementaarne brom aurustub tootest õhus, nagu iga lahusti, nii et aja jooksul ei jää mõistlikku kogust järele. HCL-i valmistamine ilma HBr-i kuivatamata - palju õnne, et saada puhtamat toodet, sest teil võib tekkida probleeme bromisooladega bromi/GAA lahuses ja bromi endaga.

 

[w2x3f5]

Ma ei näe mingeid probleeme bromi jääkide peksmisel tiosulfaadiga, seejärel viia ph aluselisse keskkonda ja koguda õli lahustiga.

 

[situ1984]

(R)-(+)-α-metüülbensüülamiin CAS-number:
3886-69-9 Kas see on kopsudest? Või imendub see maost? Kas seda võib kasutada otse?
(R)-(+)-α-metüülbensüülamiin CAS-number:
3886-69-9 Kas see pärineb kopsudest? Või imendub see maost? Kas seda võib kasutada otse?

 

[G.Patton]

Sellel ei ole psühhoefekti.

 

[amieri]

Kust saab 2,5 dimetünnitrostüreeni

 

[HerrHaber]

Henry 2,5-dimetoksübensaldehüüdi kondenseerimine nitrometaaniga primaarse amiini kui katalüsaatori juuresolekul.

 

[amieri]

It blows my mind how far I've come in this since I wrote this . You guys are all works of inspiration thanks for sharing

 

[taricshop]

kas elementaarse broomi asendamine hbr-happega on võimalik 2cb-sünteesi puhul?
@G.Patton

 

[Newbee]

@HEISENBERG @WillD @G.Patton
Question to you guys.Is it possible to perform bromination of 2ch to 2cb by NBS (N-Bromosuccinimide)
instead of elemental bromine (br2)

 

[G.Patton]

Hello.
Yes, I think so.

 

[amieri]

That's seems to be the new go to I see alot.i need to get some succinimide acid n give it a try.

 

[Newbee]

i found some writeups on thehivee but im not sure about it i also cant try do it on my own. but NBS seems to be safer to use than BR

 

[amieri]

I use a 2×2×4 grow tent in its side with a 8" inline fan going out the building as a hood up on a folding table definitely does the job,still wear a mask non the less. Make sure you have a 5% sodium thiosulphate solution on hand in case of a accident and a rubber made bin with enough of that solution to run through you glass at the end.and think every step out. You got this my friend can't wait to hear of your success.

 

[Swirly]

Yes, you can brominate with NBS on 2c-h HCl, you can read in my post.
You could even risk NBS bromination on 2c-h freebase in DCM or on the oxalate/sulfate salts.

Have a read:

https://bbgate.com/en-gb/threads/a-mostly-kitchen-friendly-synthesis-of-2c-b.13198/#post-73488

 

[amieri]

Sure you can, obviously dig as deep as you can researching hand but the fact you came this far says a lot.so keep pushing and if you waste something you at least gain the experience.now safety if thats what your concerned about thats a horse of a different color

 

[Rabidreject]

I just wanted to say thanks for this incredibly involved set of syntheses.
It is really impressive.
It’s funny, I made quite a few different nitrostyrene’s and nitropropene’s and then when I started reducing them and getting decent yields on active molecule’s, I started thinking okay, well it can’t be that much harder to produce the 2c-x compounds, then you see people making 2c-b and presumably other haloginated 2c’s and you think ah okay.

Then you start digging into the alkylated 2c compounds and my oh my does the chemistry take a jump in complexity!!

Anyway, I’m pretty convinced that my next major project is going to have to be the ethylated 4 position.
Is that a friedl-crafts alkylation you do to the 2,5-dimethoxyacetophenone, I mean in order to get from that to the 2,5-dimethoxy-1-ethylbenzene?

I think the most annoying part of it is that I’m going to have to get a vacuum pump that runs to super high vacuum!

Anyway, be prepared to be bugged by me a lot in the coming months/years because once I set my mind to something, I WILL learn how to get it done. It often involves harassing old posters! Ha