Onko kenelläkään vankkaa, todistettua n,n-DET:n synteesiä tryptamiinista?

[Rabidreject]

Kaikki on todella otsikossa, mutta rehellisesti sanottuna olisin kiinnostunut mistä tahansa ensisijaisesta tryptamiinista, joka voitaisiin valmistaa tryptamiinista - muista kuin n,n-DMT:stä.

Olen onnistunut DMT:n synteesissä tryptamiinista - mikä on mukavaa, ensimmäinen täysi lääkesynteesi. Se on mukava tunne - erilainen kuin uuttaminen, varsinkin kun useimmat ihmiset eivät yksinkertaisesti tiedä eroa!

Joka tapauksessa, jos en voi tehdä mitään muuta pieninä määrinä kokeillakseni ensimmäistä kertaa, teen suuren määrän ja myyn sen rahoittaakseni seuraavan projektini ja ehkä jopa rotovapin, koska olen superlaiska ja haluaisin tilata vähemmän kemiaa sekä tehdä vähemmän tislauksia!

Anyway yeh mulla on paljon tryptamiinia jäljellä joten....yeah lol

Olen tavallaan unohtanut kuinka paljon DMT on oikeasti arvokas. Se voi olla vain sen arvoista, että muutan kaiken DMT:ksi, koska tryptamiini on todella helppoa tulla ja mennä lol.

anyway
Luotan fiksuihin tyyppeihin. Minulla on nyt pyörivä siipipumppu, joten voin vetää pienen tyhjiön noin 1torin ympärille tai hieman yli, joten luulen, että se avaa uusia tislausmahdollisuuksia, mutta voin olla väärässä ja sillä ei ehkä ole mitään väliä haha

 

[Rabidreject]

I would like to get back to this now I have a little experience actually. I heard some good tips on a podcast surrounding this whole reductive amination reaction.
It is annoyingly finicky - I have heard that depolymerising paraformaldehyde in methanol is a bit of a game changer.

 

[mycelium]

https://www.erowid.org/library/books_online/tihkal/tihkal03.shtml

Here you go, there is an entry further down starting from tryptamine

 

[mycelium]

Can't read that on TOR, so here is copy pasta

(from tryptamine) To a solution of 1.6 g tryptamine base in 20 mL isopropanol, there was added 5.5 mL diisopropylethylamine and 2.3 mL ethyl bromide. After stirring at room temperature for 36 h the volatiles were removed under vacuum on the rotary evaporator and the light brown residue (5.17 g) was treated with 5 mL of acetic anhydride and heated in the steam bath for 5 min. After coming to room temperature, 3.5 mL ammonium hydroxide was added, and the exothermic reaction was allowed to return to room temperature. The reaction mixture was suspended in 150 mL 0.5 N H2SO4, and washed with 3x40 mL CH2Cl2. The pooled washes were again extracted with 150 mL 0.5 N H2SO4 and the aqueous phases again washed with CH2Cl2. The aqueous phases were combined, made basic with 6 N NaOH, and then extracted with 3x40 mL CH2Cl2. The pooled extracts were stripped of solvent under vacuum, and the residue (1.49 g of a dark oil with a sharp smell) was distilled at the KugelRohr. The product, N,N-diethyltryptamine, distilled at 175-185 °C at 0.05 mm/Hg to yield a white oil weighing 1.02 g, which spontaneously crystallized. This product was dissolved in 20 mL boiling hexane, cooled to room temperature, and seeded. There was thus obtained 0.72 g of a white waxy crystalline material melting at 84-87 °C. IR (in cm-1): 741, 804, 970, 1018, 1067, 1090 and 1120. MS (in m/z): C5H12N+ 86 (100%); indolemethylene+ 130 (6%); parent ion 206 (1%). The hydrochloride salt (crystallizing spontaneously from an IPA solution of the base treated with a few drops of concentrated HCl) had a mp 169-171 °C, and the following fingerprint: IR (in cm-1): 717 (br.), 759, 847, 968, 1017, 1110. This salt appears to be unstable, darkening with time.

 

[mycelium]

I know DMT in 510 cartridges like we use for THC distillate, is awesome on the dark web, they sell half gram carts. And it is relatively popular because only of convenience of carts, and DMT!
If you go that route, look up the 50ml device on cart farm, much better feel than any other cart fillers (I had the 250ml and loved it)

 

[mycelium]

I know DMT in 510 cartridges like we use for THC distillate, is awesome on the dark web, they sell half gram carts. And it is relatively popular because only of convenience of carts, and DMT!
If you go that route, look up the 50ml device on cart farm, much better feel than any other cart fillers (I had the 250ml and loved it)

 

[Rabidreject]

Oh yeah I did see shulgin’s method but that’s not from tryptamine….you could also obviously do a speeter-antony type synthesis but it’s obviously NOT something I am going to be doing in my bedroom! Ha

I would imagine using acetaldehyde instead of formaldehyde in the reductive amination would firstly remove the whole water thing, allowing you to keep it completely anhydrous, but i would imagine the slightly bulkier alkyl group to stop it being quite as prone to the competing PS reaction….just a guess tho so far. Will try it soon

 

[mycelium]

I quoted it up above, it was from tryptamine, but it wasn't at the begining of the entry, it was half way down

Here it is again:

(from tryptamine) To a solution of 1.6 g tryptamine base in 20 mL isopropanol, there was added 5.5 mL diisopropylethylamine and 2.3 mL ethyl bromide. After stirring at room temperature for 36 h the volatiles were removed under vacuum on the rotary evaporator and the light brown residue (5.17 g) was treated with 5 mL of acetic anhydride and heated in the steam bath for 5 min. After coming to room temperature, 3.5 mL ammonium hydroxide was added, and the exothermic reaction was allowed to return to room temperature. The reaction mixture was suspended in 150 mL 0.5 N H2SO4, and washed with 3x40 mL CH2Cl2. The pooled washes were again extracted with 150 mL 0.5 N H2SO4 and the aqueous phases again washed with CH2Cl2. The aqueous phases were combined, made basic with 6 N NaOH, and then extracted with 3x40 mL CH2Cl2. The pooled extracts were stripped of solvent under vacuum, and the residue (1.49 g of a dark oil with a sharp smell) was distilled at the KugelRohr. The product, N,N-diethyltryptamine, distilled at 175-185 °C at 0.05 mm/Hg to yield a white oil weighing 1.02 g, which spontaneously crystallized. This product was dissolved in 20 mL boiling hexane, cooled to room temperature, and seeded. There was thus obtained 0.72 g of a white waxy crystalline material melting at 84-87 °C. IR (in cm-1): 741, 804, 970, 1018, 1067, 1090 and 1120. MS (in m/z): C5H12N+ 86 (100%); indolemethylene+ 130 (6%); parent ion 206 (1%). The hydrochloride salt (crystallizing spontaneously from an IPA solution of the base treated with a few drops of concentrated HCl) had a mp 169-171 °C, and the following fingerprint: IR (in cm-1): 717 (br.), 759, 847, 968, 1017, 1110. This salt appears to be unstable, darkening with time.

Let us know how it works bro

 

[G.Patton]

He was looking up DET, not DMT.

 

[mycelium]

He was looking up DET, not DMT.