Sintesi del 4'-metilpropiofenone dal toluene mediante reazione di Friedel-Crafts (scala 1kg+)

[Deedubbau]

Il signor Sicurezza al soccorso....

È meglio che vi assicuriate di indossare tutti i dispositivi di protezione. Perché se seguite questo consiglio e utilizzate l'acciaio inossidabile, vi troverete tra le mani un disastro. L'acciaio inossidabile viene rapidamente attaccato dagli acidi organici e dai cloruri. Quindi, una volta scaldata questa miscela, è meglio essere preparati a correre.... oppure limitarsi al vetro

 

[amieri]

"let me show you something"

 

[NovicechemistEU]

Tomorrow I'm starting the big day synthesis with a small batch.
I wanted to start with a small batch for my first try.
1.08 mol 100 Gr 95.2 mL propionyl chloride
1.12 mol 150 Gr: AlCl₃
2.81 mol 300 ml 261 Gr Toluene
I can use 50 ml more toluene. 350 ml
Toluene of 99.5% purity was dried and then distilled under vacuum. We follow the advice of the masters

 

[William D.]

Do not forget to pour it into cold water. Not water into the reaction mixture. This is very important.

 

[Smokesalot99]

Can you replace propionyl chloride with propionic anhydride for reaction?

 

[The-Hive]

try it and let us no do it on a small scale then compare it to using propionyl chloride

 

[William D.]

Do you think this reagent is more easy to buy? And cheaper? I think this is not so, but if you have it, you can go with such a route but with correction.

 

[NovicechemistEU]

I finally managed to make the synthesis, I can't thank @William D. enough for helping me every step of the way, I am very grateful
Now I just need to distill the dirty 4'-methylpropiophenone under vacuum