Question Alfa metilcinnamaldehīda oksidēšana, izmantojot H2O2, līdz P2P ???

[skanderbeg]

Labdien, es kaut kur lasīju, iespējams, Uļā droši vien pirms 10 vai vairāk gadiem, ka ir veids, kā oksidēt alfa metilcinamaldehīdu, izmantojot H2O2 ???? Iespējams, Bayer Villiger reakcija, neesmu pārliecināts. Jautāju tāpēc, ka šo reaģentu ( CAS: 101-39-3 ) varu droši nopirkt par 40$ kg cik gribu un cik atceros tā bija reakcija ar 90% vai lielāku iznākumu. Lūdzu, atbildiet kāds!

 

[Osmosis Vanderwaal]

Yes, you can Bayer-Villager A-methylcinnamaldehyde with H2O2, but it won't get you p-2-p it will get you ....depending on the solvent time and temp, a-methyl-cinnamic acid perhaps (the carboxalic acid) or..I don't know, it's like this......P-2-P is commonly msde from cinnamaldehyde via hydrazine in diethyl glycol, which affords propynal benzene, which is oxidized by H2O2 to P-2-P. If you start at a-methylcinnamaldehyde (notidce the difference is the methyl on the alpha carbon) and go straight to peroxidation, you epoxidize it to 2-(phenoxymethyl)oxirane. Now whats interesting to me is that 2-(phenoxymethyl)oxirane is exactly BMK (benzyl-methyl-ketone) without a methyl and a carboxylic acid on the end. Methyl-carboxylic acid is better known as acetic acid. BUT WAIT THERE'S More!

Now look at this picture

this is a picture of epoxide ring opening via several routes. Look at the first on. If R was 2-(phenoxymethyl)oxirane (it can be) and you reacted it with an amine , R'-nh2, you might get something interesting. Especially if R' was methyl (makingg R'-NH2 CH3NH2, methlamine) 1 hydroxy-n-methyl-phenylethylamine. What's that mean? IDK I'm out of time to look, kids got to get on the bus!!!!!