2C-feniletilamīnu sintēze

[NarwhalFucker419]

Vai kādam ir informācija par 2C-H bromēšanu ar n-bromosukcinimīdu? Esmu redzējis, ka daži cilvēki to pieminēja citur, bet neesmu atradis nevienu aprakstu.

 

[Raxmil]

Arī es to meklēju, bet nevarēju atrast detalizētu informāciju
Zinu tikai to, ka to var darīt GAA vai DCM, bet nav priekšstata par attiecībām.

 

[amieri]

There's a person in maybe theehive on Reddit.i believe the also have a mescaline synth posted too and a few others.

 

[btcboss2022]

Man ir šaubas par 2CB sintēzes pēdējo soli. Tur ir teikts: "Reakcijas maisījumam ļāva atgriezties istabas temperatūrā, filtrēja un cietās vielas saudzīgi izskaloja ar aukstu etiķskābi." Kamēr es zinu, ka etiķskābe kļūst cieta 16-17C temperatūrā, tad ko tieši nozīmē auksta etiķskābe?
Paldies.

 

[G.Patton]

Sveiki. es pieņemu, ka aukstā skābe nozīmē istabas temperatūrā, jo ir paskaidrojums, ka reakcijas laikā izdalās siltums.

 

[btcboss2022]

Ok ok, es arī tā domāju, bet es gribēju apstiprināt, jo jūs zināt, kad mēs sakām auksts parasti mēs domājam no saldētavas nevis RT hahaha, bet ar etiķskābi tas nav iespējams ;-) paldies.

 

[w2x3f5]

Es īsti nesaprotu, kāpēc mazgā amīna hidrobromīdu, to nav iespējams lietot, tas deg. Labāk ir attīrīt un iegūt hidrohlorīdu, un zaudējumi ir mazāki, kā arī izvairīties no apšaubāmiem mēģinājumiem izmazgāt pulveri no broma.

 

[nujrc]

Es saprotu, ka atlikušais elementārais broms no produkta, tāpat kā jebkurš šķīdinātājs, iztvaikos gaisā, tāpēc ar laiku nepaliks saprātīgs daudzums. HCL izgatavošana bez HBr žāvēšanas - veiksmes, lai iegūtu tīrāku produktu, jo var nākties saskarties ar broma sāļiem broma/GAA šķīdumā un pašu bromu.

 

[w2x3f5]

Es neredzu nekādas problēmas broma atliekas pārspēt ar tiosulfātu, pēc tam ph novest līdz sārmainai videi un savākt eļļu ar šķīdinātāju.

 

[situ1984]

(R)-(+)-α-metilbenzilamīns CAS numurs:
3886-69-9 Vai tas ir no plaušām? Vai tas uzsūcas no kuņģa? Vai to var lietot tieši?
(R)-(+)-α-metilbenzilamīns CAS numurs:
3886-69-9 Vai tas nāk no plaušām? Vai to absorbē kuņģis? Vai to var lietot tieši?

 

[G.Patton]

Tam nav psiholoģiskas iedarbības.

 

[amieri]

Kur var iegādāties 2,5 dimetilnitrostirēnu

 

[HerrHaber]

Henrija 2,5-dimetoksibenzaldehīda kondensācija ar nitrometānu primārā amīna kā katalizatora klātbūtnē.

 

[amieri]

It blows my mind how far I've come in this since I wrote this . You guys are all works of inspiration thanks for sharing

 

[taricshop]

Vai ir iespējams 2cb sintēzē elementāro bromu aizstāt ar hbr skābi?
@G.Patton

 

[Newbee]

@HEISENBERG @WillD @G.Patton
Question to you guys.Is it possible to perform bromination of 2ch to 2cb by NBS (N-Bromosuccinimide)
instead of elemental bromine (br2)

 

[G.Patton]

Hello.
Yes, I think so.

 

[amieri]

That's seems to be the new go to I see alot.i need to get some succinimide acid n give it a try.

 

[Newbee]

i found some writeups on thehivee but im not sure about it i also cant try do it on my own. but NBS seems to be safer to use than BR

 

[amieri]

I use a 2×2×4 grow tent in its side with a 8" inline fan going out the building as a hood up on a folding table definitely does the job,still wear a mask non the less. Make sure you have a 5% sodium thiosulphate solution on hand in case of a accident and a rubber made bin with enough of that solution to run through you glass at the end.and think every step out. You got this my friend can't wait to hear of your success.

 

[Swirly]

Yes, you can brominate with NBS on 2c-h HCl, you can read in my post.
You could even risk NBS bromination on 2c-h freebase in DCM or on the oxalate/sulfate salts.

Have a read:

https://bbgate.com/en-gb/threads/a-mostly-kitchen-friendly-synthesis-of-2c-b.13198/#post-73488

 

[amieri]

Sure you can, obviously dig as deep as you can researching hand but the fact you came this far says a lot.so keep pushing and if you waste something you at least gain the experience.now safety if thats what your concerned about thats a horse of a different color

 

[Rabidreject]

I just wanted to say thanks for this incredibly involved set of syntheses.
It is really impressive.
It’s funny, I made quite a few different nitrostyrene’s and nitropropene’s and then when I started reducing them and getting decent yields on active molecule’s, I started thinking okay, well it can’t be that much harder to produce the 2c-x compounds, then you see people making 2c-b and presumably other haloginated 2c’s and you think ah okay.

Then you start digging into the alkylated 2c compounds and my oh my does the chemistry take a jump in complexity!!

Anyway, I’m pretty convinced that my next major project is going to have to be the ethylated 4 position.
Is that a friedl-crafts alkylation you do to the 2,5-dimethoxyacetophenone, I mean in order to get from that to the 2,5-dimethoxy-1-ethylbenzene?

I think the most annoying part of it is that I’m going to have to get a vacuum pump that runs to super high vacuum!

Anyway, be prepared to be bugged by me a lot in the coming months/years because once I set my mind to something, I WILL learn how to get it done. It often involves harassing old posters! Ha