Amfetamīna sintēze no P2NP, izmantojot SnCl2 un Zn

[Bigballen]

Cik daudz vēlamās skābes pievienot beigās?

 

[blacky2340]

Uzlejiet 10 ml acetona uz 1 ml koncentrētas 97%+ sērskābes 10:1 proporcijā. Ar pipeti vai šļirci lēnām piliniet šķīdumu, līdz tiek sasniegts pH 5,5. Ja tas ir pārskābināts, pievienot vairāk frībāzes, ja tas ir stipri pārskābināts un pārvēršas šķidrumā, tad uz a/b un pārkristalizēt.

 

[ActionAyi]

Es arī esmu domājis par toulēnu, bet man šķiet, ka blīvuma starpība ir pārāk maza, vai ne ?

 

[G.Patton]

Sveiki, paldies par ziņojumu! Tas ir patiešām interesants. 10 g amfbrīvās bāzes ir 80,4 % iznākums, diezgan labi. Cik daudz sāls jūs ieguvāt?

 

[Eleusius_hive_reboot]

i just did this synthesis successfully ! (i was very astonished, that it works, like described...!)

i used 1,7g P2NP

- created sncl2 sol. from h202 and conc HCL first, until total dissolution, quenched oxidizing agent w. Bisulfite.

- dissolved p2np in acetone / EtoH and brought solutions of sncl2/p2np-solvent together in 250ml RBF

vigourously stirred for 2hrs.

------SKIPPED OXIME ISOLATION !!!!! -----

instead gave antoher dash of conc. HCL in to the whole

and gave finely divided active-C powder a hydrogen absorber in to RM.

then three portions of Zn-dust were introduced in several heaps...with subsequent hcl/EtoH addition.

as the reagents were used up i gave a small am. of AcOH to the whole and let it further react out a 15mins.


- now i slowly alkalized to ph 12 (metal precipitates formed immediate and sank...no hassle in base extraction....did with xylene/pet.ether/naphta mixture (+a small emulsion preventing splash of 2-propanol , every extraction step...)


i pooled organic xtracts, washed them with conc.brine f. rocksalt....)

afterwards the washed org.phases were run trough fine filtering apparatus.

added a 100mls of H20 and then titrated with Hcl until ph 5,5 ~


the acidic solution was equiv. mixed with acetone / ethanol-2propanol

with concentration under stirring with surface vent.

then the pasty residue was further refined...

I OBTAINED almost 1,3g amph-hcl (hygroscopic but useable!)

so that is a fine well thought route to go, THANKS TO ORIGINAL MASTERMIND

 

[Eleusius_hive_reboot]

* MAJOR ! update:...

I DID ONE MORE "GOD-MOVE" AFTER THIS SURPRISE RESULT:.....

I SUCCEEDED IN MODIFYING THE SYNTHESIS - AND DID A REDUCTIVE AMINATION

WITH REFINED P2P AND METHYLAMMONIUMACETATE (OR KIND OF)

IT YIELDED METHAMPHETAMINE RACEMATE.... VERY UNEXPECTED QUANTITY- QUALITY AS SAME AS THE USUAL NABH4 ROUTE I PREFERRED BEFORE...


IT WENT DOWN FROM Imine formation -[ACIDIFIED VARIANT]...... TO HYDROCHLORIDE OF SLIGHT PINK APPEARANCE OVER NIGHT !

-->AT ROOM TEMPERATURE<----

PLEASE dont be mad at me but i decided to keep specifics for myself**

it is a whole new approach to phenetylamine syntheses in general ....

CREDITS TO THIS COMMUNITY PRO INSTRUCTIONAL P2P PURIFICATION TUTORIALS / I WENT TROUGH THE HASSLE OF THE WHOLE WORKUP TECHNIQUES OF THE BB-gate wisdom ...

THE PHENYLACETONE I DERIVED BY : Fe/H+ --P2NP---> Phenyl-2-Propanone


**(exception 4 you, Patton ..i made a writeup , documenting specs etc. i think you get what these
synthesis-dynamic principles hold in value )

 

[TucoSalamanca.]

No 15 gramiem p2np es ieguvu 5 gramus amfetamīna.

 

[Chemdogkm]

u recomend this reaction? Or the aluminum? Or the copper?

 

[sandman]

Es nedomāju, ka tas darbojas. Es ceru, ka tas izdosies, un man nāksies to izmēģināt.

 

[TucoSalamanca.]

Es ceru, ka tev izdosies, draugs, man neizdevās.

 

[TucoSalamanca.]

Vai esat veicis šo metodi

 

[mithyl2]

Esmu daudz reižu veicis borohidrīda metodi, bet bez panākumiem. vistuvāk tam biju, kad ieguvu apmēram 0,2 % amfetamīna. tas gan bija reāli. man ļoti vajag, lai tas izdotos, un tas mani pilnīgi tracina. dodiet mums zināt, kā veicas ar dcm.

 

[TucoSalamanca.]

Rakstīšu, mans draugs, nepalaisti garām savas lūgšanas, lai šo sintēzi varētu realizēt, paldies.

 

[TucoSalamanca.]

Es šodien nevarēju sintezēt, es to izdarīšu rīt un ziņošu.

 

[ActionAyi]

Vai ir kāds cits ekstrakcijas veids, izņemot DCM ?
Varbūt n-heksāns ?

 

[August]

Sveiki, draugi, vai šajā reakcijā neveidojas tikai feniletilamīns (PEA), vai arī es esmu vienkārši stulbs (liela iespēja).

 

[William D.]

Part of this method allows you to get phenylacetone. But stage 2 can be difficult.

 

[Amin. M]

Sveiks, mans draugs
Es izlasīju jūsu komentāru un izbaudīju to
Kā jums izdevās iegūt tīru amfetamīnu (otrajā posmā)?
Lūdzu, ieteiksiet, kura amfetamīna ražošanas metode ir labāka un galu galā tai ir augstāks tīrības procents.
Un ka viņš iegādājās izejvielas, izmantojot veikalu
(Man nav profesionālas laboratorijas)

 

[michelAMPH]

Zonder de kosten van 300 gram P2NP .
alle grondstoffen voor 200 gram amfetamine free base kosten hier €416,68???
Mooi recept alleen het kan totaal niet uit