So easy and cheap dont know why you use DCM to extract the ephedrine freebase the toulene or xylene polarity is better for extracting freebases and dont form side product when adding NaOH, do you know what stereoisomers of ephedrine are produced is it reacemic ?
By employing this method all four diastereoisomers will be formed in variable concentration, one chiral carbon atom (the one with the nitrogen) will have its chirality dictated by the ephedrone. The oxo(keto) reduction yields racemic alcohols with borohydride but carrot slices can do the trick and finish with a single pair of enantiomers, the tedious workup would become the problem in this case.
By employing this method all four diastereoisomers will be formed in variable concentration, one chiral carbon atom (the one with the nitrogen) will have its chirality dictated by the ephedrone. The oxo(keto) reduction yields racemic alcohols with borohydride but carrot slices can do the trick and finish with a single pair of enantiomers, the tedious workup would become the problem in this case.
In that case not many advantages than P2P route.
Another option could be make the enantiomer resolution to the ephedrone but not sure how it will works and you would keep the levo isomer to later process the levo ephedrine to reduce it and obtain dextro meth.
Resolving ephedrine before reducing it to meth would be so stupid that nobody with the actual skill to resolve it would ever do it in practice. Therefore you are right.
I think the only shortcoming of this video is that it doesn't split the ephedrine because what you get is mixed ephedrine. I think no one in our forum is willing to split ephedrine and share the video. If someone does, he is a great chemist. Or a better way is to reduce it to mixed methamphetamine and then split it
I think the only shortcoming of this video is that it doesn't split the ephedrine because what you get is mixed ephedrine. I think no one in our forum is willing to split ephedrine and share the video. If someone does, he is a great chemist. Or a better way is to reduce it to mixed methamphetamine and then split it
Introduction In this article, a detailed description of d-methamphetamine hydrochloride synthesis via tartaric acid was represented. This isomer separation approach is the easiest and most popular among clandestine chemists. It's reasoned by cheap and affordable d,l-Tartaric acid (CAS 133-37-9)...
So easy and cheap dont know why you use DCM to extract the ephedrine freebase the toulene or xylene polarity is better for extracting freebases and dont form side product when adding NaOH, do you know what stereoisomers of ephedrine are produced is it reacemic ?
Separation of racemate into enantiomers is a headache and many hours of work. But the fact remains that reducing a mixture of ephedrine isomers with HI in the presence of red P as a catalyst will result in a racemic mixture of methamphetamine isomers that will surpass D-methamphetamine alone in terms of taste and effects. This is just my own opinion about my experience in this matter, because, after all, discussing flavors is a waste of calories.
In that case not many advantages than P2P route.
Another option could be make the enantiomer resolution to the ephedrone but not sure how it will works and you would keep the levo isomer to later process the levo ephedrine to reduce it and obtain dextro meth.
Yeah btcboss2022 I was reading on some of the original workups, way back when they first started employing synthetic routes to (-)ephedrine, > resolved intermediate prior to reduction to E, then another rxn ( I don’t recall the catalys, they did use one though) to yield (+)PSE
I like The idea of getting the racemate isolated early then carying out rx to desired product. To bad methylamine is asymmetric.. you on to any chiral rxn from ketone? I know Hydrogenlysis shit looks a bit over My head
Yeah btcboss2022 I was reading on some of the original workups, way back when they first started employing synthetic routes to (-)ephedrine, > resolved intermediate prior to reduction to E, then another rxn ( I don’t recall the catalys, they did use one though) to yield (+)PSE
I like The idea of getting the racemate isolated early then carying out rx to desired product. To bad methylamine is asymmetric.. you on to any chiral rxn from ketone? I know Hydrogenlysis shit looks a bit over My head
So easy and cheap dont know why you use DCM to extract the ephedrine freebase the toulene or xylene polarity is better for extracting freebases and dont form side product when adding NaOH, do you know what stereoisomers of ephedrine are produced is it reacemic ?
You could reduce ephedrone (methcathinone) to methamphetamine with hydroiodic acid and red phosphorus if your goal is making meth. No need to turn it into ephedrine in the first place.
You could reduce ephedrone (methcathinone) to methamphetamine with hydroiodic acid and red phosphorus if your goal is making meth. No need to turn it into ephedrine in the first place.
It depends on what ephedrone you're working it. If it's L-ephedrone then D-meth should be produced (same as L-ephedrine derived from plants produces D-meth). If it's a racemic mixture then you'd obtain racemic meth.
You could reduce ephedrone (methcathinone) to methamphetamine with hydroiodic acid and red phosphorus if your goal is making meth. No need to turn it into ephedrine in the first place.
Yes.
Alternatively you could use LiAlH4 to reduce it to meth. But there are much better routes than this one. I just wanted to point out that if you have methcathinone on hand, you could reduce it to meth directly rather than making ephedrine from it first.
Yes.
Alternatively you could use LiAlH4 to reduce it to meth. But there are much better routes than this one. I just wanted to point out that if you have methcathinone on hand, you could reduce it to meth directly rather than making ephedrine from it first.
No birch? If iodine and red p works i dont see why other one wouldnt. Im having issues gettin the p2np synth to amine to work correctly so im looking for help on that and other alternatives
“Does mephedrone also have the correct properties to do that? Or just cathinone?”
Yes. HI with red phosphorus can reduce alcohols and ketones to corresponding alkanes. Mephedrone (just like methcathinone) has a ketone group at the same position as methcathinone.
No birch? If iodine and red p works i dont see why other one wouldnt. Im having issues gettin the p2np synth to amine to work correctly so im looking for help on that and other alternatives
Birch reduction (for reasons to me unknown) eliminates the hydroxyl group next to the phenyl ring. I am therefore not confident that it would eliminate carbonyls (ketones in this case) too.
Hm,still good to know.u have experience with p2np synth, amalgum or copper ?trying to get those to work but having troubles with yield and end product,reaction goes well,just the rest im messn up somwhere cuz its not correct
