Synthesis difference between jwh-210 and jwh-018

[rotovap5002]

Is the only synthesis between these cannabinoids is that you replace the 1-naphthoyl for jwh-018 with 4-Ethyl-1-naphthoyl chloride for jwh-210?

 

[William D.]

Only slightly change the proportions. Otherwise, everything is the same.

 

[Matty018]

Can someone advise me on this please ?

I have done THE STAGE 3 and the results is like in form of oil,

What should i do to get a liquid so that i can soak my A4 paper in it ?? If possible whats the best solvent should i use ?

Thanks

Stage 3. JWH-018 Synthesis​

19. Previously purified 3-(1-naphthoyl)indole 100 g is poured into a flask.
20. Sodium hydroxide 50 g is added.
21. Next, TBAB (tetrabutylammonium bromide) 25 g is added.
22. Water 200 ml is poured into the flask.
23. 1-Bromopentane 75 g is added.
24. A stirrer is turned on.
25. The reaction mixture in the flask is self-heated. An external heating is turned on until the mixture starts to boil. The boiling point is maintained for 15-30 min, depending on a boiling intensity.
26. A 1-bromopentane excess will be evaporated into an atmosphere (use proper ventilation). Reflux condencer is installed.
27. After a while, the mixture is poured into a beaker. The mixture is left for a layers separation.
28. The desired top layer is collected. The collected top layer is transferred into a separate vessel.
29. The oil is cooled down to room temperature (this procedure also helps to evaporate a 1-bromopentane excess if it is still there).