Synthese van 4'-methylpropiofenon uit tolueen door Friedel-Crafts reactie (schaal 1kg+)

[Deedubbau]

Mr. Veiligheid aan de redder ....

Ja, je kunt er maar beter voor zorgen dat je al die beschermende kleding draagt. Want als je dit advies opvolgt en roestvast staal gebruikt, dan ga je een ramp tegemoet. Roestvrij staal wordt snel aangetast door organische zuren en chloriden. Dus als je deze mix opwarmt, kun je maar beter voorbereid zijn om te rennen.... of gewoon glas gebruiken.

 

[amieri]

"let me show you something"

 

[NovicechemistEU]

Tomorrow I'm starting the big day synthesis with a small batch.
I wanted to start with a small batch for my first try.
1.08 mol 100 Gr 95.2 mL propionyl chloride
1.12 mol 150 Gr: AlCl₃
2.81 mol 300 ml 261 Gr Toluene
I can use 50 ml more toluene. 350 ml
Toluene of 99.5% purity was dried and then distilled under vacuum. We follow the advice of the masters

 

[William D.]

Do not forget to pour it into cold water. Not water into the reaction mixture. This is very important.

 

[Smokesalot99]

Can you replace propionyl chloride with propionic anhydride for reaction?

 

[The-Hive]

try it and let us no do it on a small scale then compare it to using propionyl chloride

 

[William D.]

Do you think this reagent is more easy to buy? And cheaper? I think this is not so, but if you have it, you can go with such a route but with correction.

 

[NovicechemistEU]

I finally managed to make the synthesis, I can't thank @William D. enough for helping me every step of the way, I am very grateful
Now I just need to distill the dirty 4'-methylpropiophenone under vacuum