Drug Repurposing. Molecular Aspects and Therapeutic Applications, K. Saxena, London, United Kingdom, 2022 by IntechOpen, 367 p.
Print ISBN 978-1-83969-957-3
Online ISBN 978-1-83969-958-0
eBook (PDF) ISBN 978-1-83969-959-7
This book focuses on various aspects and applications of drug repurposing, the understanding of which is important for treating diseases. Due to the high costs and time associated with the new drug discovery process, the inclination toward drug repurposing is increasing for common as well as rare diseases. A major focus of this book is understanding the role of drug repurposing to develop drugs for infectious diseases, including antivirals, antibacterial and anticancer drugs, as well as immunotherapeutics.
Contents
Preface
Section 1
Drug Repurposing for Infectious Diseases
Chapter 1
Trends in Molecular Aspects and Therapeutic Applications of Drug Repurposing for Infectious Diseases by Ankur Gupta, Angila Theengh, Swatantra Kumar, Vimal K. Maurya, Santosh Kumar, Bipin Puri and Shailendra K. Saxena
Section 2
Drug Repurposing for Antiviral Drug Discovery
Chapter 2
Evaluation of Drug Repositioning by Molecular Docking of Pharmaceutical Resources to Identification of Potential SARS-CoV-2 Viral Inhibitors
by Fatemeh Hosseini, Mehrdad Azin, Hamideh Ofoghi and Tahereh Alinejad
Chapter 3
Drug Repurposing Techniques in Viral Diseases by Ran Zhang, Rick Oerlemans, Chao Wang, Lili Zhang and Matthew R. Groves
Section 3
Drug Repurposing for Antibacterial Drug Discovery
Chapter 4
Antituberculosis Drug Repurposing: A New Hope for Tackling Multi-Challenging TB in Timely Manner by Shahnawaz Majeed, Safiya Mehraj and Zahoor Ahmad
Chapter 5
Drug Repurposing for Tuberculosis by Nicole C. Cardoso, Carel B. Oosthuizen, Nashied Peton and Vinayak Singh
Section 4
Drug Repurposing for Anticancer Drug Discovery
Chapter 6
Breast Cancer Drug Repurposing a Tool for a Challenging Disease by Jonaid Ahmad Malik, Rafia Jan, Sakeel Ahmed and Sirajudheen Anwar
Chapter 7
The Future Perspectives of Drug Repurposing and Treatment for the Drug Resistant Breast Cancer: A Review by Panneerselvam Theivendren, Selvaraj Kunjiappan, Yashoda Mariappa Hegde, Kaveena Ravi, Sivakumar Vellaichamy, Murugananthan Gopal and Manimekalai Pichaivel
Chapter 8
Repurposing of Metformin as a Multifaceted and Multitasking Preventative and Treatment for Cancer by Raymond Chang
Chapter 9
Ivermectin: Potential Repurposing of a Versatile Antiparasitic as a Novel Anticancer by Alfonso Dueñas-González and Mandy Juárez-Rodríguez
Chapter 10
Progesterone and Glucocorticoid Receptor Modulator Mifepristone (RU-486) as Treatment for Advanced Cancers by Jerome H. Check and Diane L. Check
Section 5
Drug Repurposing for Immunotherapeutic Drug Discovery
Chapter 11
Integrating Immunotherapy with Chemotherapy: A New Approach to Drug Repurposing by Hina Qayoom, Umar Mehraj, Shariqa Aisha, Shazia Sofi
and Manzoor Ahmad Mir
Chapter 12
Role of Activated Cdc42-Associated Kinase 1 (ACK1/TNK2)-Inhibitors in Precision Oncology by Ruby Srivastava
Section 6
Pharmacogenomics Based Drug Repurposing for Novel Drug Discovery
Chapter 13
Gene Signature-Based Drug Repositioning by Zhilong Jia, Xinyu Song, Jinlong Shi, Weidong Wang and Kunlun He
Chapter 14
Recent Progress in Drug Repurposing Using Protein Variants and Amino Acids in Disease Phenotypes/Disorders by Michael P. Okoh and Lukman A. Alli
Chapter 15
Repurposing Market Drugs to Target Epigenetic Enzymes in Human Diseases by Aishat Motolani, Matthew Martin, Steven Sun and Tao Lu
Section 7
Natural Product Based Drug Repurposing for Novel Drug Discovery
Chapter 16
Therapeutic Inhibitors: Natural Product Options through Computer-Aided Drug Design by InnocentMary IfedibaluChukwu Ejiofor, Christabel Chikodili Ekeomodi, Sharon Elomeme and MaryGeraldine Ebele Ejiofor
Print ISBN 978-1-83969-957-3
Online ISBN 978-1-83969-958-0
eBook (PDF) ISBN 978-1-83969-959-7
This book focuses on various aspects and applications of drug repurposing, the understanding of which is important for treating diseases. Due to the high costs and time associated with the new drug discovery process, the inclination toward drug repurposing is increasing for common as well as rare diseases. A major focus of this book is understanding the role of drug repurposing to develop drugs for infectious diseases, including antivirals, antibacterial and anticancer drugs, as well as immunotherapeutics.
Contents
Preface
Section 1
Drug Repurposing for Infectious Diseases
Chapter 1
Trends in Molecular Aspects and Therapeutic Applications of Drug Repurposing for Infectious Diseases by Ankur Gupta, Angila Theengh, Swatantra Kumar, Vimal K. Maurya, Santosh Kumar, Bipin Puri and Shailendra K. Saxena
Section 2
Drug Repurposing for Antiviral Drug Discovery
Chapter 2
Evaluation of Drug Repositioning by Molecular Docking of Pharmaceutical Resources to Identification of Potential SARS-CoV-2 Viral Inhibitors
by Fatemeh Hosseini, Mehrdad Azin, Hamideh Ofoghi and Tahereh Alinejad
Chapter 3
Drug Repurposing Techniques in Viral Diseases by Ran Zhang, Rick Oerlemans, Chao Wang, Lili Zhang and Matthew R. Groves
Section 3
Drug Repurposing for Antibacterial Drug Discovery
Chapter 4
Antituberculosis Drug Repurposing: A New Hope for Tackling Multi-Challenging TB in Timely Manner by Shahnawaz Majeed, Safiya Mehraj and Zahoor Ahmad
Chapter 5
Drug Repurposing for Tuberculosis by Nicole C. Cardoso, Carel B. Oosthuizen, Nashied Peton and Vinayak Singh
Section 4
Drug Repurposing for Anticancer Drug Discovery
Chapter 6
Breast Cancer Drug Repurposing a Tool for a Challenging Disease by Jonaid Ahmad Malik, Rafia Jan, Sakeel Ahmed and Sirajudheen Anwar
Chapter 7
The Future Perspectives of Drug Repurposing and Treatment for the Drug Resistant Breast Cancer: A Review by Panneerselvam Theivendren, Selvaraj Kunjiappan, Yashoda Mariappa Hegde, Kaveena Ravi, Sivakumar Vellaichamy, Murugananthan Gopal and Manimekalai Pichaivel
Chapter 8
Repurposing of Metformin as a Multifaceted and Multitasking Preventative and Treatment for Cancer by Raymond Chang
Chapter 9
Ivermectin: Potential Repurposing of a Versatile Antiparasitic as a Novel Anticancer by Alfonso Dueñas-González and Mandy Juárez-Rodríguez
Chapter 10
Progesterone and Glucocorticoid Receptor Modulator Mifepristone (RU-486) as Treatment for Advanced Cancers by Jerome H. Check and Diane L. Check
Section 5
Drug Repurposing for Immunotherapeutic Drug Discovery
Chapter 11
Integrating Immunotherapy with Chemotherapy: A New Approach to Drug Repurposing by Hina Qayoom, Umar Mehraj, Shariqa Aisha, Shazia Sofi
and Manzoor Ahmad Mir
Chapter 12
Role of Activated Cdc42-Associated Kinase 1 (ACK1/TNK2)-Inhibitors in Precision Oncology by Ruby Srivastava
Section 6
Pharmacogenomics Based Drug Repurposing for Novel Drug Discovery
Chapter 13
Gene Signature-Based Drug Repositioning by Zhilong Jia, Xinyu Song, Jinlong Shi, Weidong Wang and Kunlun He
Chapter 14
Recent Progress in Drug Repurposing Using Protein Variants and Amino Acids in Disease Phenotypes/Disorders by Michael P. Okoh and Lukman A. Alli
Chapter 15
Repurposing Market Drugs to Target Epigenetic Enzymes in Human Diseases by Aishat Motolani, Matthew Martin, Steven Sun and Tao Lu
Section 7
Natural Product Based Drug Repurposing for Novel Drug Discovery
Chapter 16
Therapeutic Inhibitors: Natural Product Options through Computer-Aided Drug Design by InnocentMary IfedibaluChukwu Ejiofor, Christabel Chikodili Ekeomodi, Sharon Elomeme and MaryGeraldine Ebele Ejiofor
