Alan F. Casy, Robert T. Parfitt Opioid Analgesics. Chemistry and Receptors. Springer New York, NY, 1986, 518 p. ISBN 978-1-4899-0585-7 doi.org/10.1007/978-1-4899-0585-7
The rapidly burgeoning research of the past two decades on agonist-antagonist analgesics and opioid receptors makes this exhaustive review of opioid analgesics particularly relevant and timely. After an introductory chapter the additional 12 chapters begin logically with morphine and congeners (4,5-epoxymorphinans) and end with opioid receptors. All principal chemical types of centrally acting analgesics (including endogenous opioid-like substances) and their antagonists as well as the mixed agonist-antagonists are treated thoroughly, although not always (and for good reason) in historical (chronological) order. A chapter on miscellaneous types (atypical structures for (he most part) includes the benzimidazoles (etonitazene), aminotetralins (dezocine), tetrahydroisoquinolines (methopholine), and so on. Important aspects and correlations of chemistry, pharmacology, and biochemistry are discussed in depth. Literature citations are numerous. For educators, practicing laboratory scientists, and physicians, this scholarly review by two authors well versed in the chemistry, pharmacology, and biochemistry of opioid analgesics will be informative, stimulating, and thought-provoking.
The rapidly burgeoning research of the past two decades on agonist-antagonist analgesics and opioid receptors makes this exhaustive review of opioid analgesics particularly relevant and timely. After an introductory chapter the additional 12 chapters begin logically with morphine and congeners (4,5-epoxymorphinans) and end with opioid receptors. All principal chemical types of centrally acting analgesics (including endogenous opioid-like substances) and their antagonists as well as the mixed agonist-antagonists are treated thoroughly, although not always (and for good reason) in historical (chronological) order. A chapter on miscellaneous types (atypical structures for (he most part) includes the benzimidazoles (etonitazene), aminotetralins (dezocine), tetrahydroisoquinolines (methopholine), and so on. Important aspects and correlations of chemistry, pharmacology, and biochemistry are discussed in depth. Literature citations are numerous. For educators, practicing laboratory scientists, and physicians, this scholarly review by two authors well versed in the chemistry, pharmacology, and biochemistry of opioid analgesics will be informative, stimulating, and thought-provoking.
