Sinteza 25B-NBOME iz benzaldehidov z nitrometanom
- Thread starter William D.
- Start date
Verjetno govorim samo sam s sabo, vendar se zdi, da bi bilo lažje reducirati nitrostiren naravnost na 2,5 MO-PEA s pomočjo Zn in HCl...
- By William D.
Ne, ne smete izpustiti enega samega koraka, če ste prejeli nenasičeno snov ali izgubili izkoristek. Ocetna kislina s cinkom v brezvodnih pogojih lahko deluje bolje. Če le ne vzamete brezvodne HCl kisline.
Sploh se ne pogovarjate sami s seboj. To je zame zelo zanimiv članek, za katerega zbiram zaloge, da bi ga preizkusil. Všeč mi je zamisel o tako močnem psihedeliku! Nikoli ne bi bil neodgovoren z njim in ga poskušal izdati za kislino - to je po mojem mnenju uničilo te droge. Spremenilo je pogled ljudi na nbome, ko so ljudje začeli umirati, ker so mediji želeli le pikantno zgodbo!
Osebno sem jih VEDNO doziral odgovorno in ugotovil, da so dobra psihedelika! Tudi imeti 2cb na prvem mestu bi bilo čudovito, priznajmo si to. Morda bom moral kupiti 1/2 kg 2,5-dmo benzaldehida. (Dobesedno zato, ker ne najdem nikogar, ki bi mu zaupal, da bi mi prodal manj kot to!). Z 2,5-dmo benzaldehidom lahko narediš toliko različnih stvari, da čeprav je do končnega izdelka več korakov, kot če bi kupil triptamin, je dejstvo, da s triptaminom ne moreš narediti toliko stvari, ki bi me zanimale kot fenetilamini - zaradi tolerance imam raje zelo psihedelične fenetilamine kot triptamine (na splošno - obstaja nekaj izstopajočih).
Gotta love alibaba...
Osebno sem jih VEDNO doziral odgovorno in ugotovil, da so dobra psihedelika! Tudi imeti 2cb na prvem mestu bi bilo čudovito, priznajmo si to. Morda bom moral kupiti 1/2 kg 2,5-dmo benzaldehida. (Dobesedno zato, ker ne najdem nikogar, ki bi mu zaupal, da bi mi prodal manj kot to!). Z 2,5-dmo benzaldehidom lahko narediš toliko različnih stvari, da čeprav je do končnega izdelka več korakov, kot če bi kupil triptamin, je dejstvo, da s triptaminom ne moreš narediti toliko stvari, ki bi me zanimale kot fenetilamini - zaradi tolerance imam raje zelo psihedelične fenetilamine kot triptamine (na splošno - obstaja nekaj izstopajočih).
Gotta love alibaba...
- By Sue
Poskusite ga prebrati, vas morda zanima?
SINTEZA N-(HALOGENIRANIH) BENZILNIH ANALOGOV SUPERPOTENTNIH SEROTONINSKIH LIGANDOV
J. Chil. Chem. Soc., 59, Nº 3 (2014)
Leta 2003 so predhodne raziskave pripeljale do zaključka, da je N-2-
metoksibenzilna substitucija, ne le fenilentilaminov, temveč tudi
fenilizopropilaminov, triptaminov in 3-(2-aminoetil)-(1H,3H)
kvinazolin-2,4-dione, povezane s tipičnim antagonistom receptorjev 5-HT2
ketanserinom, povzročajo posebno visoko afiniteto do receptorjev 5-HT2A.5
Vsi, ki jih poznam, imajo 25I raje kot 25B in 25C, saj je odličen psihedelik in lahek za um...
SINTEZA N-(HALOGENIRANIH) BENZILNIH ANALOGOV SUPERPOTENTNIH SEROTONINSKIH LIGANDOV
J. Chil. Chem. Soc., 59, Nº 3 (2014)
Leta 2003 so predhodne raziskave pripeljale do zaključka, da je N-2-
metoksibenzilna substitucija, ne le fenilentilaminov, temveč tudi
fenilizopropilaminov, triptaminov in 3-(2-aminoetil)-(1H,3H)
kvinazolin-2,4-dione, povezane s tipičnim antagonistom receptorjev 5-HT2
ketanserinom, povzročajo posebno visoko afiniteto do receptorjev 5-HT2A.5
Vsi, ki jih poznam, imajo 25I raje kot 25B in 25C, saj je odličen psihedelik in lahek za um...
- By Rabidreject
mislim, da sem morda slišal za ta dokument, bom pogledal....
vem, da je kemija trenutno daleč nad mojo glavo, v praktičnem smislu.
Še vedno poskušam zmanjšati 3,4,5-TMONS, ki sem ga naredil, na ustrezen PEA. Enkrat mi je to uspelo v zelo slabih izkoristkih z metodo NaBH4/CuCl2, vendar še ne dovolj za uporabo. V svoji zbirki vzorcev imam nekaj različnih nitrostirenov/nitropropenov, zato sem si rekel, da bom delal s tistim, ki ga imam največ, dokler mi ne uspe!
vem, da je kemija trenutno daleč nad mojo glavo, v praktičnem smislu.
Še vedno poskušam zmanjšati 3,4,5-TMONS, ki sem ga naredil, na ustrezen PEA. Enkrat mi je to uspelo v zelo slabih izkoristkih z metodo NaBH4/CuCl2, vendar še ne dovolj za uporabo. V svoji zbirki vzorcev imam nekaj različnih nitrostirenov/nitropropenov, zato sem si rekel, da bom delal s tistim, ki ga imam največ, dokler mi ne uspe!
Imam težave s pridobivanjem 2-metoksibenzaldehida za korak 4, ga lahko nadomestim s 4-metoksibenzaldehidom ali obstaja priporočilo za drugo spojino?
- By tripeep
@WillD Pozdravljeni, gospod, imam težave s pridobivanjem 2-metoksibenzaldehida za korak 4, ali ga lahko nadomestim s 4-metoksibenzaldehidom ali obstaja priporočilo za drugo spojino?
- By HIGGS BOSSON
It will be an analogue of NBOme, with a lower psychoactive potency, but I think it will work. As an experiment, it can be synthesized, but the issue of biotests should be approached carefully at such low dosages of these compounds.
Issues i have with this:
° i think you are attempting to form edda in situ from ethylene diamine and acetic acid? Probably works but its not worth the slightly lower yield for the minimal time saved.
° amino acid catalysts produce far better yields for henrys (1)
° WHAT EVEN IS THAT REDUCTION OF A NITROALKENE LMAOOOOO
makes no sense even in just grammatical terms 
° nbs bromination is superior even bromination with bromine has always worked out better for me than hbr (anecdotal however check both the hive and the vesp)
° Wtf is Et3N? im assuming triethylamine? what the fuck is that doing there lmao yeah it just doesnt need that X3(2)
° 30mins to 3hrs? yeah 1.5hr is perfect(3)
° This seems to literally just be scaled up without testing (although i somehow doubt op has any chem experience so i dont blame them) but this is a rather simple synthesis easily available online as either ralf hiems stuff, or the journal of chilean chemical society.
° WAY WAY too fucking much ethylene diamine assuming a density of 0.9g per ml 200ml = 180g which = 2.995 moles assuming a 75% yield of EDDA in situ (hopeful thinking considering rhodium supposedly got that separately) we would achieve roughly 2.2 moles which is enough for 22moles subbed aldehyde
° Some of my favourite quotes from here include :
"Extraction and distilled"
"500 g yellow oil (propane)"
”240 g base yellow oil."
You should also note that salicylaldehyde is acceptable for instead producing NBOHs an easier to find precursor being found naturally too (meadowsweet) (it can also be prepared through reimer tiemann like 2-methoxy but have you ever tried one? They fucking suck bad yield dirty reaction)p
bai bai yall ^w^ <3 :3
(1) https://link.springer.com/article/10.1007/s10562-022-04228-4
(2) https://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072014000300022 and page 233 of ralf hiems experimental
(3) page 233 of ralph hiems experimental (ss attached)
° i think you are attempting to form edda in situ from ethylene diamine and acetic acid? Probably works but its not worth the slightly lower yield for the minimal time saved.
° amino acid catalysts produce far better yields for henrys (1)
° WHAT EVEN IS THAT REDUCTION OF A NITROALKENE LMAOOOOO
makes no sense even in just grammatical terms ° nbs bromination is superior even bromination with bromine has always worked out better for me than hbr (anecdotal however check both the hive and the vesp)
° Wtf is Et3N? im assuming triethylamine? what the fuck is that doing there lmao yeah it just doesnt need that X3(2)
° 30mins to 3hrs? yeah 1.5hr is perfect(3)
° This seems to literally just be scaled up without testing (although i somehow doubt op has any chem experience so i dont blame them) but this is a rather simple synthesis easily available online as either ralf hiems stuff, or the journal of chilean chemical society.
° WAY WAY too fucking much ethylene diamine assuming a density of 0.9g per ml 200ml = 180g which = 2.995 moles assuming a 75% yield of EDDA in situ (hopeful thinking considering rhodium supposedly got that separately) we would achieve roughly 2.2 moles which is enough for 22moles subbed aldehyde
° Some of my favourite quotes from here include :
"Extraction and distilled"
"500 g yellow oil (propane)"
”240 g base yellow oil."
You should also note that salicylaldehyde is acceptable for instead producing NBOHs an easier to find precursor being found naturally too (meadowsweet) (it can also be prepared through reimer tiemann like 2-methoxy but have you ever tried one? They fucking suck bad yield dirty reaction)p
bai bai yall ^w^ <3 :3
(1) https://link.springer.com/article/10.1007/s10562-022-04228-4
(2) https://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072014000300022 and page 233 of ralf hiems experimental
(3) page 233 of ralph hiems experimental (ss attached)