Sinteza amfetamina iz P2NP prek SnCl2 in Zn

[Bigballen]

Koliko želene kisline je treba dodati na koncu?

 

[blacky2340]

Na 1 ml koncentrirane žveplove kisline v razmerju 10:1 nalijte 10 ml acetona. S pipeto ali brizgalko počasi kapljajte raztopino, dokler ne dosežete pH 5,5. Če je prekislinjena, dodajte več proste baze, če je močno prekislinjena in se spremeni v tekočino, potem v a/b in ponovno kristalizirajte.

 

[ActionAyi]

Razmišljal sem tudi o toulenu, vendar mislim, da je razlika v gostoti premajhna, mar ne ?

 

[G.Patton]

Pozdravljeni, hvala za vaše poročilo! Res je zanimivo. 10 g proste amfobaz je 80,4-odstotni izkoristek, kar je precej dobro. Koliko soli ste dobili?

 

[Eleusius_hive_reboot]

i just did this synthesis successfully ! (i was very astonished, that it works, like described...!)

i used 1,7g P2NP

- created sncl2 sol. from h202 and conc HCL first, until total dissolution, quenched oxidizing agent w. Bisulfite.

- dissolved p2np in acetone / EtoH and brought solutions of sncl2/p2np-solvent together in 250ml RBF

vigourously stirred for 2hrs.

------SKIPPED OXIME ISOLATION !!!!! -----

instead gave antoher dash of conc. HCL in to the whole

and gave finely divided active-C powder a hydrogen absorber in to RM.

then three portions of Zn-dust were introduced in several heaps...with subsequent hcl/EtoH addition.

as the reagents were used up i gave a small am. of AcOH to the whole and let it further react out a 15mins.


- now i slowly alkalized to ph 12 (metal precipitates formed immediate and sank...no hassle in base extraction....did with xylene/pet.ether/naphta mixture (+a small emulsion preventing splash of 2-propanol , every extraction step...)


i pooled organic xtracts, washed them with conc.brine f. rocksalt....)

afterwards the washed org.phases were run trough fine filtering apparatus.

added a 100mls of H20 and then titrated with Hcl until ph 5,5 ~


the acidic solution was equiv. mixed with acetone / ethanol-2propanol

with concentration under stirring with surface vent.

then the pasty residue was further refined...

I OBTAINED almost 1,3g amph-hcl (hygroscopic but useable!)

so that is a fine well thought route to go, THANKS TO ORIGINAL MASTERMIND

 

[Eleusius_hive_reboot]

* MAJOR ! update:...

I DID ONE MORE "GOD-MOVE" AFTER THIS SURPRISE RESULT:.....

I SUCCEEDED IN MODIFYING THE SYNTHESIS - AND DID A REDUCTIVE AMINATION

WITH REFINED P2P AND METHYLAMMONIUMACETATE (OR KIND OF)

IT YIELDED METHAMPHETAMINE RACEMATE.... VERY UNEXPECTED QUANTITY- QUALITY AS SAME AS THE USUAL NABH4 ROUTE I PREFERRED BEFORE...


IT WENT DOWN FROM Imine formation -[ACIDIFIED VARIANT]...... TO HYDROCHLORIDE OF SLIGHT PINK APPEARANCE OVER NIGHT !

-->AT ROOM TEMPERATURE<----

PLEASE dont be mad at me but i decided to keep specifics for myself**

it is a whole new approach to phenetylamine syntheses in general ....

CREDITS TO THIS COMMUNITY PRO INSTRUCTIONAL P2P PURIFICATION TUTORIALS / I WENT TROUGH THE HASSLE OF THE WHOLE WORKUP TECHNIQUES OF THE BB-gate wisdom ...

THE PHENYLACETONE I DERIVED BY : Fe/H+ --P2NP---> Phenyl-2-Propanone


**(exception 4 you, Patton ..i made a writeup , documenting specs etc. i think you get what these
synthesis-dynamic principles hold in value )

 

[TucoSalamanca.]

Iz 15 gramov p2np sem dobil 5 gramov amfetamina.

 

[Chemdogkm]

u recomend this reaction? Or the aluminum? Or the copper?

 

[sandman]

Mislim, da to ne deluje. Upam, da deluje, in bom moral poskusiti.

 

[TucoSalamanca.]

Upam, da ti bo uspelo, kolega, meni ni.

 

[TucoSalamanca.]

Ali ste že izvedli to metodo

 

[mithyl2]

metodo z borohidridom sem uporabil že večkrat in brez uspeha. najbližje sem bil, ko sem naredil približno 0,2-odstotni izkoristek amfetamina. vendar je bil pravi. zelo potrebujem, da to deluje, in to me popolnoma spravlja ob pamet. sporočite nam, kako gre dcm.

 

[TucoSalamanca.]

Pisal bom, prijatelj, ne zamudite svojih molitev, da bo ta sinteza lahko uresničena, hvala.

 

[TucoSalamanca.]

Danes nisem mogel sintetizirati, to bom storil jutri in o tem poročal.

 

[ActionAyi]

Ali obstaja kakšen drug način za pridobivanje izvlečka kot DCM ?
Morda n-heksan?

 

[August]

Pozdravljeni prijatelji, ali pri tej reakciji ne nastane samo feniletilamin (PEA) ali sem samo neumen (velika možnost)

 

[William D.]

Part of this method allows you to get phenylacetone. But stage 2 can be difficult.

 

[Amin. M]

Pozdravljen, moj prijatelj
prebral sem vaš komentar in užival v njem
Kako ste dobili čisti amfetamin (v drugem koraku)?
Prosim, svetujte, katera metoda pridobivanja amfetamina je boljša in ima na koncu večji odstotek čistosti
In da je surovine nabavil prek trgovine
(nimam profesionalnega laboratorija)

 

[michelAMPH]

Zonder de kosten van 300 gram P2NP .
alle grondstoffen voor 200 gram amfetamine free base kosten hier €416,68???
Mooi recept alleen het kan totaal niet uit