Synthesis of 4-Methylpropiophenone: Methods & Procedures

Guide to 4-Methylpropiophenone Synthesis: Comprehensive Methodologies

The organic synthesis world has been enriched by the production of compounds like 4’-methylpropiophenone. This article covers the in-depth methodologies for 4’-methylpropiophenone synthesis and its brominated derivative, 2-bromo-4'-methylpropiophenone (cas 1451-82-7). Here’s a step-by-step approach using two solvents: Dichloromethane (DCM) and Acetic acid.

Materials Required:

Reagents:

• 4-methylpropiophenone (cas 5337-93-9): 1000 g
• Dichloromethane (DCM) or Glacial acetic acid (GAA): 3000 ml
• Bromine (Br2): 1080g or 348 ml
• Sodium bicarbonate (NaHCO3) solution
• Distilled water
• Magnesium sulphate (MgSO4)

Equipment and Glassware:

[List retained from the original]

Safety Note for Handling Bromine:

Bromine's orange-red fumes possess a sharp smell and present significant risks. Avoid skin contact as it can result in severe burns and ulcers. Inhaling its vapors can cause irritation in the nose and throat. Ensure all operations with bromine are carried out in a fume hood wearing protective equipment. 

When transferring bromine, use a conical funnel, secured above the flask with a retort stand, ensuring the funnel tip is within the flask. Always maintain the cleanliness of apparatus connections, especially when dealing with drip funnels.

Synthesis in DCM:

Synthesis in Acetic Acid:

Conclusion:

The synthesis of 4’-methylpropiophenone and its derivatives offers immense potential for various applications. It's essential to approach the process with precision, an insight of each step's intricacies, and always prioritizing safety.