Guide to 2-bromo-4'-methylpropiophenone Synthesis

Guide to 2-bromo-4'-methylpropiophenone Synthesis

The organic synthesis world has been enriched by the production of compounds like 2-bromo-4'-methylpropiophenone. This article covers the in-depth 2-bromo-4'-methylpropiophenone (cas 1451-82-7) synthesis. Bromination reaction is easily scaled under these conditions. Basic rule: hydrogen peroxide is added slowly in order to avoid the reaction mixture splashing. It is better to use a top stirrer because a magnetic stirrer doesn't cope with the sediment. Blades of stirrer must be covered with ftoroplast (Teflon) in order to avoid reactions with hydrobromic (HBr) acid.

Reagents:

• 4′-Methylpropiophenone (cas 5337-93-9) 1000 g;
• Hydrobromic acid 48% aq. 1300 g;
• Hydrogen peroxide (H2O2) 35% 750 g;
• Sodium bicarbonate (NaHCO3);
• Distilled water;

Equipment and Glassware:

• Three necked round bottom flask 5 L;
• Retort stand and clamp for securing apparatus;
• Reflux condenser;
• Funnel;
• Drip funnel 1 L;
• Top stirrer;
• Sieve filter (kitchen grade is ok);
• Water bath;
• Heating plate;
• Syringe or Pasteur pipette;
• pH indicator papers;
• Beakers (600 mL x2, 2 L, 1 L, 100 mL x2);
• Vacuum source;
• Laboratory scale (0.1-1000 g is suitable);
• Measuring cylinders 1000 mL and 100 mL;
• Glass rod and spatula;
• Laboratory grade thermometer;
• Buchner flask and funnel;
• Filter paper;

2-Bromo-4'-methylpropiophenone Synthesis

Conclusion

The synthesis of 2-bromo-4'-methylpropiophenone and its derivatives offers immense potential for various applications. It's essential to approach the process with precision, an insight of each step's intricacies, and always prioritizing safety.

Bibliography

Gaspar, Helena, et al. "Proactive response to tackle the threat of emerging drugs: Synthesis and toxicity evaluation of new cathinones." Forensic science international 290 (2018): 146-156. https://www.sciencedirect.com/science/article/abs/pii/S0379073818303797